HIV-associated oral Kaposi sarcoma and HHV-8: a review.

Liviu Feller*, Johan Lemmer, Neil H. Wood, Yusuf Jadwat, Erich J. Raubenheimer

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)


Kaposi sarcoma is the most common malignant tumour associated with HIV infection. In the majority of cases oral tissues are involved and in 22% the initial presentation is in the oral cavity. The oral lesions are either single or multifocal, and the palate, gingiva and tongue are the sites most frequently involved. The pathogenesis of Kaposi sarcoma in HIV-seropositive subjects is complex. It involves interaction between human herpesvirus-8 (HHV-8) and HIV, altered cellular signal transduction pathways, and increased production of cytokines and growth factors. The multifactorial nature and clinical stages in the growth of oral Kaposi sarcoma are discussed.

Original languageEnglish
Pages (from-to)129-136
Number of pages8
JournalJournal of the International Academy of Periodontology
Issue number4
Publication statusPublished - Oct 2007
Externally publishedYes


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