TY - JOUR
T1 - HIV infection as risk factor for death among hospitalized persons with Candidemia, South Africa, 2012-2017
AU - GERMS-SA
AU - Govender, Nelesh P.
AU - Todd, Jim
AU - Nel, Jeremy
AU - Mer, Mervyn
AU - Karstaedt, Alan
AU - Cohen, Cheryl
AU - Black, John
AU - Abrahams, Shareef
AU - Pearce, Vanessa
AU - Hoosen, Anwar
AU - Kleinhans, Vicky
AU - Moncho, Masego
AU - Maluleka, Caroline
AU - Verwey, Charl
AU - Feldman, Charles
AU - Moore, David
AU - Reubenson, Gary
AU - Han, Khine Swe Swe
AU - Wadula, Jeannette
AU - Lindeque, Kathy
AU - Nchabeleng, Maphoshane
AU - Samodien, Nazlee
AU - du Plessis, Nicolette
AU - Mbelle, Nontombi
AU - Maningi, Nontuthuko
AU - Bosman, Norma
AU - Kularatne, Ranmini
AU - Seetharam, Sharona
AU - Thomas, Teena
AU - Avenant, Theunis
AU - Nana, Trusha
AU - Chibabhai, Vindana
AU - Maharj, Adhil
AU - Burra, Asmeeta
AU - Naby, Fathima
AU - Dawood, Halima
AU - Mogamberry, Jade
AU - Mlisana, Koleka
AU - Sookan, Lisha
AU - Ramjathan, Praksha
AU - Mahabeer, Prasha
AU - Naidoo, Romola
AU - Haffejee, Sumayya
AU - Coovadia, Yacoob
AU - Dlamini, Nomonde
AU - Sirkar, Surendra
AU - Hamese, Ken
AU - Sibiya, Ngoaka
AU - Lekalakala, Ruth
AU - Hoyland, Greta
N1 - Publisher Copyright:
© 2021 Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2021/6
Y1 - 2021/6
N2 - We determined the effect of HIV infection on deaths among persons >18 months of age with culture-confirmed candidemia at 29 sentinel hospitals in South Africa during 2012-2017. Of 1,040 case-patients with documented HIV status and in-hospital survival data, 426 (41%) were HIV-seropositive. The in-hospital case-fatality rate was 54% (228/426) for HIV-seropositive participants and 37% (230/614) for HIV-seronegative participants (crude odds ratio [OR] 1.92, 95% CI 1.50-2.47; p<0.001). After adjusting for relevant confounders (n = 907), mortality rates were 1.89 (95% CI 1.38-2.60) times higher among HIV-seropositive participants than HIV-seronegative participants (p<0.001). Compared with HIV-seronegative persons, the stratum-specific adjusted mortality OR was higher among HIV-seropositive persons not managed in intensive care units (OR 2.27, 95% CI 1.47-3.52; p<0.001) than among persons who were (OR 1.56, 95% CI 1.00-2.43; p = 0.05). Outcomes among HIV-seropositive persons with candidemia might be improved with intensive care.
AB - We determined the effect of HIV infection on deaths among persons >18 months of age with culture-confirmed candidemia at 29 sentinel hospitals in South Africa during 2012-2017. Of 1,040 case-patients with documented HIV status and in-hospital survival data, 426 (41%) were HIV-seropositive. The in-hospital case-fatality rate was 54% (228/426) for HIV-seropositive participants and 37% (230/614) for HIV-seronegative participants (crude odds ratio [OR] 1.92, 95% CI 1.50-2.47; p<0.001). After adjusting for relevant confounders (n = 907), mortality rates were 1.89 (95% CI 1.38-2.60) times higher among HIV-seropositive participants than HIV-seronegative participants (p<0.001). Compared with HIV-seronegative persons, the stratum-specific adjusted mortality OR was higher among HIV-seropositive persons not managed in intensive care units (OR 2.27, 95% CI 1.47-3.52; p<0.001) than among persons who were (OR 1.56, 95% CI 1.00-2.43; p = 0.05). Outcomes among HIV-seropositive persons with candidemia might be improved with intensive care.
UR - http://www.scopus.com/inward/record.url?scp=85106496116&partnerID=8YFLogxK
U2 - 10.3201/eid2706.210128
DO - 10.3201/eid2706.210128
M3 - Review article
C2 - 34014153
AN - SCOPUS:85106496116
SN - 1080-6040
VL - 27
SP - 1607
EP - 1615
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 6
ER -
