Human papillomavirus and carcinoma of the mucosal surfaces of the head and neck

Erich Raubenheimer; Thomas Slavik; Lou Lemmer; Henno Olivier; Willie van Heerden; Hilde Miniggio

doi:10.1016/j.ajoms.2017.08.003

Human papillomavirus and carcinoma of the mucosal surfaces of the head and neck

Erich Raubenheimer^*, Thomas Slavik, Lou Lemmer, Henno Olivier, Willie van Heerden, Hilde Miniggio

^*Corresponding author for this work

Oral Biology

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

Human papillomavirus induced cervical cancer is the fourth most prevalent malignancy affecting females globally. Over the past two decades scientific information unveiled an increasing role for the virus in the pathogenesis of malignancies developing from the mucosal surfaces of the oropharynx. It is feasible to postulate that we may be in the beginning of a global pandemic of oropharyngeal cancer if the mode of transmission of the virus is taken into account. The main goals of this manuscript are to present a brief summary of the mechanisms of human papillomavirus induced malignant transformation, provide guidelines for the microscopic diagnosis of high risk human papillomavirus involvement in mucosal biopsies and highlight the implications thereof in cancers of the mucosal surfaces of the head and neck.

Original language	English
Pages (from-to)	55-59
Number of pages	5
Journal	Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.ajoms.2017.08.003
Publication status	Published - Jan 2018

Keywords

HPV 16
High risk HPV infection
Oropharyngeal cancer
p16

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ajoms.2017.08.003

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title = "Human papillomavirus and carcinoma of the mucosal surfaces of the head and neck",

abstract = "Human papillomavirus induced cervical cancer is the fourth most prevalent malignancy affecting females globally. Over the past two decades scientific information unveiled an increasing role for the virus in the pathogenesis of malignancies developing from the mucosal surfaces of the oropharynx. It is feasible to postulate that we may be in the beginning of a global pandemic of oropharyngeal cancer if the mode of transmission of the virus is taken into account. The main goals of this manuscript are to present a brief summary of the mechanisms of human papillomavirus induced malignant transformation, provide guidelines for the microscopic diagnosis of high risk human papillomavirus involvement in mucosal biopsies and highlight the implications thereof in cancers of the mucosal surfaces of the head and neck.",

keywords = "HPV 16, High risk HPV infection, Oropharyngeal cancer, p16",

author = "Erich Raubenheimer and Thomas Slavik and Lou Lemmer and Henno Olivier and {van Heerden}, Willie and Hilde Miniggio",

note = "Publisher Copyright: {\textcopyright} 2017 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI",

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doi = "10.1016/j.ajoms.2017.08.003",

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T1 - Human papillomavirus and carcinoma of the mucosal surfaces of the head and neck

AU - Raubenheimer, Erich

AU - Slavik, Thomas

AU - Lemmer, Lou

AU - Olivier, Henno

AU - van Heerden, Willie

AU - Miniggio, Hilde

PY - 2018/1

Y1 - 2018/1

N2 - Human papillomavirus induced cervical cancer is the fourth most prevalent malignancy affecting females globally. Over the past two decades scientific information unveiled an increasing role for the virus in the pathogenesis of malignancies developing from the mucosal surfaces of the oropharynx. It is feasible to postulate that we may be in the beginning of a global pandemic of oropharyngeal cancer if the mode of transmission of the virus is taken into account. The main goals of this manuscript are to present a brief summary of the mechanisms of human papillomavirus induced malignant transformation, provide guidelines for the microscopic diagnosis of high risk human papillomavirus involvement in mucosal biopsies and highlight the implications thereof in cancers of the mucosal surfaces of the head and neck.

AB - Human papillomavirus induced cervical cancer is the fourth most prevalent malignancy affecting females globally. Over the past two decades scientific information unveiled an increasing role for the virus in the pathogenesis of malignancies developing from the mucosal surfaces of the oropharynx. It is feasible to postulate that we may be in the beginning of a global pandemic of oropharyngeal cancer if the mode of transmission of the virus is taken into account. The main goals of this manuscript are to present a brief summary of the mechanisms of human papillomavirus induced malignant transformation, provide guidelines for the microscopic diagnosis of high risk human papillomavirus involvement in mucosal biopsies and highlight the implications thereof in cancers of the mucosal surfaces of the head and neck.

KW - HPV 16

KW - High risk HPV infection

KW - Oropharyngeal cancer

KW - p16

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DO - 10.1016/j.ajoms.2017.08.003

M3 - Review article

AN - SCOPUS:85029153141

SN - 2212-5558

VL - 30

SP - 55

EP - 59

JO - Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

JF - Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

IS - 1

ER -

Human papillomavirus and carcinoma of the mucosal surfaces of the head and neck

Abstract

Keywords

UN SDGs

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