TY - JOUR
T1 - Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1
T2 - human papillomavirus-mediated carcinogenesis.
AU - Feller, Liviu
AU - Wood, Neil H.
AU - Khammissa, Razia A.G.
AU - Lemmer, Johan
PY - 2010
Y1 - 2010
N2 - High-risk human papillomavirus (HPV) E6 and E7 oncoproteins are essential factors for HPV-induced carcinogenesis, and for the maintenance of the consequent neoplastic growth. Cellular transformation is achieved by complex interaction of these oncogenes with several cellular factors of cell cycle regulation including p53, Rb, cyclin-CDK complexes, p21 and p27. Both persistent infection with high-risk HPV genotypes and immune dysregulation are associated with increased risk of HPV-induced squamous cell carcinoma.
AB - High-risk human papillomavirus (HPV) E6 and E7 oncoproteins are essential factors for HPV-induced carcinogenesis, and for the maintenance of the consequent neoplastic growth. Cellular transformation is achieved by complex interaction of these oncogenes with several cellular factors of cell cycle regulation including p53, Rb, cyclin-CDK complexes, p21 and p27. Both persistent infection with high-risk HPV genotypes and immune dysregulation are associated with increased risk of HPV-induced squamous cell carcinoma.
UR - http://www.scopus.com/inward/record.url?scp=77954552752&partnerID=8YFLogxK
M3 - Review article
C2 - 20633288
AN - SCOPUS:77954552752
SN - 1746-160X
VL - 6
SP - 14
JO - Head and Face Medicine
JF - Head and Face Medicine
ER -
