Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: human papillomavirus-mediated carcinogenesis.

Liviu Feller; Neil H. Wood; Razia A.G. Khammissa; Johan Lemmer

Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: human papillomavirus-mediated carcinogenesis.

Liviu Feller^*
, Neil H. Wood
, Razia A.G. Khammissa
, Johan Lemmer

^*Corresponding author for this work

Periodontology and Oral Medicine

Research output: Contribution to journal › Review article › peer-review

55 Citations (Scopus)

Abstract

High-risk human papillomavirus (HPV) E6 and E7 oncoproteins are essential factors for HPV-induced carcinogenesis, and for the maintenance of the consequent neoplastic growth. Cellular transformation is achieved by complex interaction of these oncogenes with several cellular factors of cell cycle regulation including p53, Rb, cyclin-CDK complexes, p21 and p27. Both persistent infection with high-risk HPV genotypes and immune dysregulation are associated with increased risk of HPV-induced squamous cell carcinoma.

Original language	English
Pages (from-to)	14
Number of pages	1
Journal	Head and Face Medicine
Volume	6
Publication status	Published - 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

@article{c22fee46042e465aa359e486e6fc960f,

title = "Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: human papillomavirus-mediated carcinogenesis.",

abstract = "High-risk human papillomavirus (HPV) E6 and E7 oncoproteins are essential factors for HPV-induced carcinogenesis, and for the maintenance of the consequent neoplastic growth. Cellular transformation is achieved by complex interaction of these oncogenes with several cellular factors of cell cycle regulation including p53, Rb, cyclin-CDK complexes, p21 and p27. Both persistent infection with high-risk HPV genotypes and immune dysregulation are associated with increased risk of HPV-induced squamous cell carcinoma.",

author = "Liviu Feller and Wood, \{Neil H.\} and Khammissa, \{Razia A.G.\} and Johan Lemmer",

year = "2010",

language = "English",

volume = "6",

pages = "14",

journal = "Head and Face Medicine",

issn = "1746-160X",

publisher = "BioMed Central Ltd.",

}

TY - JOUR

T1 - Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1

T2 - human papillomavirus-mediated carcinogenesis.

AU - Feller, Liviu

AU - Wood, Neil H.

AU - Khammissa, Razia A.G.

AU - Lemmer, Johan

PY - 2010

Y1 - 2010

N2 - High-risk human papillomavirus (HPV) E6 and E7 oncoproteins are essential factors for HPV-induced carcinogenesis, and for the maintenance of the consequent neoplastic growth. Cellular transformation is achieved by complex interaction of these oncogenes with several cellular factors of cell cycle regulation including p53, Rb, cyclin-CDK complexes, p21 and p27. Both persistent infection with high-risk HPV genotypes and immune dysregulation are associated with increased risk of HPV-induced squamous cell carcinoma.

AB - High-risk human papillomavirus (HPV) E6 and E7 oncoproteins are essential factors for HPV-induced carcinogenesis, and for the maintenance of the consequent neoplastic growth. Cellular transformation is achieved by complex interaction of these oncogenes with several cellular factors of cell cycle regulation including p53, Rb, cyclin-CDK complexes, p21 and p27. Both persistent infection with high-risk HPV genotypes and immune dysregulation are associated with increased risk of HPV-induced squamous cell carcinoma.

UR - https://www.scopus.com/pages/publications/77954552752

M3 - Review article

C2 - 20633288

AN - SCOPUS:77954552752

SN - 1746-160X

VL - 6

SP - 14

JO - Head and Face Medicine

JF - Head and Face Medicine

ER -

Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: human papillomavirus-mediated carcinogenesis.

Abstract

UN SDGs

Other files and links

Fingerprint

Cite this