Immobilized Sulfuric Acid on Silica Gel as Highly Efficient and Heterogeneous Catalyst for the One-Pot Synthesis of Novel α-Acyloxycarboxamides in Aqueous Media

Sodeeq Aderotimi Salami*, Meloddy Manyeruke, Xavier Siwe-Noundou, Rui Werner Maçedo Krause

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The application of immobilized sulfuric acid on silica gel (H2SO4-SiO2) as an efficient and easily reusable solid catalyst was explored in the synthesis of novel α-acyloxycarboxamide derivatives via a Passerini reaction of benzoic acid, aldehyde/ketone, and isocyanides. The Passerini adducts were obtained in high to excellent yields within 10 min in aqueous media under catalytic conditions. The key advantages of the process include a short reaction time, high yields, the catalyst’s low cost, and the catalyst’s reusability.

Original languageEnglish
Article number9529
JournalInternational Journal of Molecular Sciences
Volume23
Issue number17
DOIs
Publication statusPublished - Sep 2022
Externally publishedYes

Keywords

  • aqueous media
  • immobilized sulfuric acid on silica gel
  • passerini reaction
  • α-acyloxycarboxamides

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