Immunopathogenic oral diseases: An overview focusing on pemphigus vulgaris and mucous membrane pemphigoid

Liviu Feller*, Raoul Ballyram, Razia A.G. Khammissa, Mario Altini, Johan Lemmer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Summary: Pemphigus vulgaris, mucosal pemphigoid (mucous membrane pemphigoid), lichen planus, discoid lupus erythematosus and erythema multiforme are a group of immune-mediated mucocutaneous disorders characterised clinically by the formation of blisters, erosions or ulcers. The oral mucosa is often affected, and sometimes the disease is limited to the mouth. The target antigens, autoreactive immune responses, microscopic features, treatment and prognosis vary from one disease to the other. Treatment aims to eliminate exogenous risk factors, suppress the pathogenic immuno-inflammatory reactions, promote healing and prevent infection. The aim of this article is to provide the general dental practitioner with a succinct overview of the diagnostic, clinical, aetiopathogenic features and characteristics of, as well as treatment guidelines for oral pemphigus vulgaris and oral mucosal pemphigoid. Early diagnosis and treatment could prevent severe consequences of the disease in their full-blown forms.

Original languageEnglish
Pages (from-to)177-182
Number of pages6
JournalOral health & preventive dentistry
Volume15
Issue number2
DOIs
Publication statusPublished - 2017

Keywords

  • Autoreactive antibodies
  • Blisters
  • Desmosomes
  • Desquamative gingivitis
  • Hemidesmosomes
  • Immunemediated mucocutaneous disorders
  • Immunofluorescence

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