Impact of nucleotide polymorphisms at drug resistance sites on genetic barrier in human immunodeficiency virus type 1 subtype C resistance evolution

Benson Chuks Iweriebor; Tracy Masebe; Julius Nwobegahay; Jeffrey M. Mphahlele; Pascal Obong Bessong

doi:10.5897/AJB10.1580

Impact of nucleotide polymorphisms at drug resistance sites on genetic barrier in human immunodeficiency virus type 1 subtype C resistance evolution

Benson Chuks Iweriebor, Tracy Masebe, Julius Nwobegahay, Jeffrey M. Mphahlele, Pascal Obong Bessong

Virological Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

Genetic diversity is the hallmark of human immunodeficiency virus (HIV), the causative agent of acquired immune deficiency syndrome (AIDS). This diversity has resulted in a spectrum of different subtypes within the group M viruses that is responsible for the AIDS pandemic. Nucleotide substitutions and polymorphisms at codons known to confer drug resistance in subtype B viruses were compared with similar substitutions in subtype C viruses. Genetic barrier was determined on viruses isolated from drug naive patients infected with subtype C viruses. We found a reduced genetic barrier in subtype C viruses at codon V106M (GTA to ATG) and an increased barrier at codon L210W (TTA/CTG/CTA to TGG) when compared to subtype B consensus. The highest genetic barrier in subtype C viruses is found at codon Q151M where two transversions or each one of transition and transversion are needed for the resistance evolution.

Original language	English
Pages (from-to)	15320-15326
Number of pages	7
Journal	African Journal of Biotechnology
Volume	10
Issue number	68
DOIs	https://doi.org/10.5897/AJB10.1580
Publication status	Published - 2 Nov 2011

Keywords

Drug resistance
Genetic barrier
Human immunodeficiency virus (HIV)
Non-b subtypes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5897/AJB10.1580

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title = "Impact of nucleotide polymorphisms at drug resistance sites on genetic barrier in human immunodeficiency virus type 1 subtype C resistance evolution",

abstract = "Genetic diversity is the hallmark of human immunodeficiency virus (HIV), the causative agent of acquired immune deficiency syndrome (AIDS). This diversity has resulted in a spectrum of different subtypes within the group M viruses that is responsible for the AIDS pandemic. Nucleotide substitutions and polymorphisms at codons known to confer drug resistance in subtype B viruses were compared with similar substitutions in subtype C viruses. Genetic barrier was determined on viruses isolated from drug naive patients infected with subtype C viruses. We found a reduced genetic barrier in subtype C viruses at codon V106M (GTA to ATG) and an increased barrier at codon L210W (TTA/CTG/CTA to TGG) when compared to subtype B consensus. The highest genetic barrier in subtype C viruses is found at codon Q151M where two transversions or each one of transition and transversion are needed for the resistance evolution.",

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AU - Iweriebor, Benson Chuks

AU - Masebe, Tracy

AU - Nwobegahay, Julius

AU - Mphahlele, Jeffrey M.

AU - Bessong, Pascal Obong

PY - 2011/11/2

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AB - Genetic diversity is the hallmark of human immunodeficiency virus (HIV), the causative agent of acquired immune deficiency syndrome (AIDS). This diversity has resulted in a spectrum of different subtypes within the group M viruses that is responsible for the AIDS pandemic. Nucleotide substitutions and polymorphisms at codons known to confer drug resistance in subtype B viruses were compared with similar substitutions in subtype C viruses. Genetic barrier was determined on viruses isolated from drug naive patients infected with subtype C viruses. We found a reduced genetic barrier in subtype C viruses at codon V106M (GTA to ATG) and an increased barrier at codon L210W (TTA/CTG/CTA to TGG) when compared to subtype B consensus. The highest genetic barrier in subtype C viruses is found at codon Q151M where two transversions or each one of transition and transversion are needed for the resistance evolution.

KW - Drug resistance

KW - Genetic barrier

KW - Human immunodeficiency virus (HIV)

KW - Non-b subtypes

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Impact of nucleotide polymorphisms at drug resistance sites on genetic barrier in human immunodeficiency virus type 1 subtype C resistance evolution

Abstract

Keywords

UN SDGs

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