Impact of nucleotide polymorphisms at drug resistance sites on genetic barrier in human immunodeficiency virus type 1 subtype C resistance evolution

Benson Chuks Iweriebor, Tracy Masebe, Julius Nwobegahay, Jeffrey M. Mphahlele, Pascal Obong Bessong

Research output: Contribution to journalArticlepeer-review

Abstract

Genetic diversity is the hallmark of human immunodeficiency virus (HIV), the causative agent of acquired immune deficiency syndrome (AIDS). This diversity has resulted in a spectrum of different subtypes within the group M viruses that is responsible for the AIDS pandemic. Nucleotide substitutions and polymorphisms at codons known to confer drug resistance in subtype B viruses were compared with similar substitutions in subtype C viruses. Genetic barrier was determined on viruses isolated from drug naive patients infected with subtype C viruses. We found a reduced genetic barrier in subtype C viruses at codon V106M (GTA to ATG) and an increased barrier at codon L210W (TTA/CTG/CTA to TGG) when compared to subtype B consensus. The highest genetic barrier in subtype C viruses is found at codon Q151M where two transversions or each one of transition and transversion are needed for the resistance evolution.

Original languageEnglish
Pages (from-to)15320-15326
Number of pages7
JournalAfrican Journal of Biotechnology
Volume10
Issue number68
DOIs
Publication statusPublished - 2 Nov 2011
Externally publishedYes

Keywords

  • Drug resistance
  • Genetic barrier
  • Human immunodeficiency virus (HIV)
  • Non-b subtypes

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