In vivo evaluation of the effects of continuous exercise on skeletal muscle triglycerides in trained humans

J. Rico-Sanz, M. Moosavi, E. L. Thomas, J. McCarthy, G. A. Coutts, N. Saeed, J. D. Bell

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

Magnetic resonance spectroscopy “1H MRS” and imaging “MRI” were used to investigate the effects of a bout of moderate prolonged exercise on intra “IMCL”- and extramyocellular lipid “EMCL” utilization in the soleus, tibialis anterior, and gastrocnemius muscles of five trained human subjects. MRI and 1H MRS measurements were obtained before and after a 90 min run on a calibrated treadmill at a velocity corresponding to 64 ± 1.5% of each subjects' maximal rate of oxygen consumption. There were significant decreases in IMCL following exercise in the tibialis “pre: 22.37 ± 4.33 vs. post: 15.16 ± 3.25 mmol/kg dry wt; P < 0.01” and soleus “pre: 36.93 ± 1.45 vs. post: 29.85 ± 2.44 mmol/kg dry wt; P < 0.01” muscles. There was also a decrease in the gastrocnemius muscle, although this did not reach the level of significance “pre: 33.78 ± 5.35 vs. post: 28.48 ± 5.44 mmol/kg dry weight; P < 0.10”. No significant changes were observed in EMCL or subcutaneous fat. In conclusion, this study showed that IMCL were significantly utilized in the tibialis and soleus muscles of aerobically endurance-trained humans. The absence of significant utilization of IMCL in the gastrocnemius may reflect differences in fiber type and/of intensity of contraction for each muscle group.

Original languageEnglish
Pages (from-to)1313-1318
Number of pages6
JournalLipids
Volume35
Issue number12
DOIs
Publication statusPublished - 2000
Externally publishedYes

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