Increased exposure to hepatitis B virus infection in HIV-positive South African antenatal women

R. J. Burnett, J. M. Ngobeni, G. François, A. A. Hoosen, G. Leroux-Roels, A. Meheus, M. J. Mphahlele

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28 Citations (Scopus)

Abstract

The prevalence of markers for hepatitis B virus (HBV) exposure and active infection in HIV-positive (n = 710) and HIV-negative (n = 710) pregnant South African women was investigated. The following statistically significant increases in the HIV-positive group were found: anti-hepatitis B core antigen (anti-HBc) (37.3% versus 28.6%; odds ratio [OR]: 1.49); antihepatitis B surface antigen (anti-HBs) (29.5% versus 20.1%; OR: 1.66); exposure based on hepatitis B surface antigen (HBsAg) and anti-HBc (39.2% versus 30.1%; OR: 1.49); and exposure based on anti-HBs, anti-HBc and HBsAg (37.1% versus 24.5%; OR: 1.82). However, there was no increase in active HBV infections, with 2.4% of the HIV positives and 2.2% of the HIV negatives being HBV DNA positive. Although the impact that HIV has had on the prevalence of HBV in this population group is not as pronounced as that found in areas of low endemicity (where up to seven-fold increases have been reported), there is a statistically significant increased exposure to HBV.

Original languageEnglish
Pages (from-to)152-156
Number of pages5
JournalInternational Journal of STD and AIDS
Volume18
Issue number3
DOIs
Publication statusPublished - Mar 2007

Keywords

  • HBV
  • HBV/HIV co-infection
  • HIV
  • South Africa
  • Sub-Saharan Africa

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