Influence of container on vitamin A stability in TPN admixtures

D. P. Bluhm*, R. S. Summers, M. M.J. Lowes, H. H. Dürrheim

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Losses of vitamin A from a paediatric TPN lipid emulsion stored at 30°C under ward lighting and from an aqueous glucose/amino acid solution stored at 2-8°C in the dark were determined when different containers were used. Vitamin A assay was performed by reverse-phase HPLC. In the first instance, a PVC bag and a Buretrol showed little difference in t90% (20 days and > 21 days, respectively). In the second case, t90% in both a PVC bag and a glass container was ∼- 12 days. Hence, the material of the container has little effect on vitamin A stability in these two admixtures.

Original languageEnglish
Pages (from-to)281-283
Number of pages3
JournalInternational Journal of Pharmaceutics
Issue number1-3
Publication statusPublished - 1 Feb 1991


  • Buretrol
  • Glass container
  • PVC bag
  • TPN
  • Vitamin A


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