Insights into immunopathogenic mechanisms of HIV infection: high levels of immune activation and HIV fitness.

L. Feller; R. A. Khammissa; N. H. Wood; R. Meyerov; J. Lemmer

Insights into immunopathogenic mechanisms of HIV infection: high levels of immune activation and HIV fitness.

L. Feller^*, R. A. Khammissa, N. H. Wood, R. Meyerov, J. Lemmer

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

Abstract

Progressive diminution in the number, and decline in the function of CD4+ T cells are the hallmarks of HIV infection. The pathogenic mechanisms responsible for the progression of the disease to acquired immunodeficiency syndrome (AIDS) are not well understood, but it appears that HIV-induced immune activation and increase in HIV viral fitness play an essential role in the pathogenesis of HIV infection. In this paper HIV fitness in relation to the chronic immune activation in HIV infection will be discussed.

Original language	English
Pages (from-to)	552, 554, 556-557
Journal	SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging
Volume	63
Issue number	10
Publication status	Published - Nov 2008
Externally published	Yes

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title = "Insights into immunopathogenic mechanisms of HIV infection: high levels of immune activation and HIV fitness.",

abstract = "Progressive diminution in the number, and decline in the function of CD4+ T cells are the hallmarks of HIV infection. The pathogenic mechanisms responsible for the progression of the disease to acquired immunodeficiency syndrome (AIDS) are not well understood, but it appears that HIV-induced immune activation and increase in HIV viral fitness play an essential role in the pathogenesis of HIV infection. In this paper HIV fitness in relation to the chronic immune activation in HIV infection will be discussed.",

author = "L. Feller and Khammissa, {R. A.} and Wood, {N. H.} and R. Meyerov and J. Lemmer",

year = "2008",

month = nov,

language = "English",

volume = "63",

pages = "552, 554, 556--557",

journal = "SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging",

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Insights into immunopathogenic mechanisms of HIV infection: high levels of immune activation and HIV fitness. / Feller, L.; Khammissa, R. A.; Wood, N. H. et al.
In: SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging, Vol. 63, No. 10, 11.2008, p. 552, 554, 556-557.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Insights into immunopathogenic mechanisms of HIV infection

T2 - high levels of immune activation and HIV fitness.

AU - Feller, L.

AU - Khammissa, R. A.

AU - Wood, N. H.

AU - Meyerov, R.

AU - Lemmer, J.

PY - 2008/11

Y1 - 2008/11

N2 - Progressive diminution in the number, and decline in the function of CD4+ T cells are the hallmarks of HIV infection. The pathogenic mechanisms responsible for the progression of the disease to acquired immunodeficiency syndrome (AIDS) are not well understood, but it appears that HIV-induced immune activation and increase in HIV viral fitness play an essential role in the pathogenesis of HIV infection. In this paper HIV fitness in relation to the chronic immune activation in HIV infection will be discussed.

AB - Progressive diminution in the number, and decline in the function of CD4+ T cells are the hallmarks of HIV infection. The pathogenic mechanisms responsible for the progression of the disease to acquired immunodeficiency syndrome (AIDS) are not well understood, but it appears that HIV-induced immune activation and increase in HIV viral fitness play an essential role in the pathogenesis of HIV infection. In this paper HIV fitness in relation to the chronic immune activation in HIV infection will be discussed.

UR - http://www.scopus.com/inward/record.url?scp=65649137321&partnerID=8YFLogxK

M3 - Review article

C2 - 19322966

AN - SCOPUS:65649137321

SN - 1029-4864

VL - 63

SP - 552, 554, 556-557

JO - SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging

JF - SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging

IS - 10

ER -

Insights into immunopathogenic mechanisms of HIV infection: high levels of immune activation and HIV fitness.

Abstract

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