Progressive diminution in the number, and decline in the function of CD4+ T cells are the hallmarks of HIV infection. The pathogenic mechanisms responsible for the progression of the disease to acquired immunodeficiency syndrome (AIDS) are not well understood, but it appears that HIV-induced immune activation and increase in HIV viral fitness play an essential role in the pathogenesis of HIV infection. In this paper HIV fitness in relation to the chronic immune activation in HIV infection will be discussed.
|Pages (from-to)||552, 554, 556-557|
|Journal||SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging|
|Publication status||Published - Nov 2008|