Lipid emulsion content and vitamin A stability in TPN admixtures

D. P. Bluhm*, R. S. Summers, M. M.J. Lowes, H. H. Dürrheim

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Vitamin A stability in TPN regimens may be influenced by the different lipid content in lipid, 3-in-1 and aqueous admixtures. In this study vitamin A losses were investigated by HPLC, in a paediatric lipid emulsion, a paediatric 3-in-1 admixture, an adult aqueous glucose/amino acid admixture and an adult 3-in-1 admixture. The admixtures were stored in PVC containers under typical storage and administration conditions. Pharmaceutically significant vitamin A losses under storage conditions occurred only from the paediatric 3-in-1 admixture. These losses could have been caused by the presence of trace elements from Ped-el®. On exposure to ward light and temperature, the only admixture with a t90% less than 24 h was the adult aqueous admixture. Under these conditions there was an inverse linear correlation between fat content and vitamin A loss. Fat emulsions in TPN afford protection from light to vitamin A. Hence, the vitamin should be added to lipid emulsions where possible.

Original languageEnglish
Pages (from-to)277-280
Number of pages4
JournalInternational Journal of Pharmaceutics
Issue number1-3
Publication statusPublished - 1 Feb 1991


  • Fat emulsion
  • Photodegradation
  • TPN
  • Vitamin A


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