TY - JOUR
T1 - Malignant nodular melanoma of the vulva
T2 - A rare and aggressive tumour of the female genital tract (case report)
AU - Khaba, Moshawa Calvin
AU - Lekala, Matsiane Luciah
AU - Mosehle, Setheme Daniel
N1 - Publisher Copyright:
© 2021, African Field Epidemiology Network. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Malignant melanoma of the vulva is a rare and aggressive tumour with dismal prognosis. It tends to recur and metastasize early. Surgical excision with or without regional lymph node dissection is still the treatment of choice with adjuvant therapy decided on a case by case. Furthermore, HIV infection has been associated with more aggressive disease. Herein we present a 45-year-old HIV-infected female patient on antiretroviral therapy who presented with vulval ulcer for one year. On examination, she had ulcerated nodule on the labia majora. Radiology showed vulvovaginal tumour without involvement of the adjacent organs. Malignant melanoma was confirmed on both the incisional biopsy and vulvectomy. She responded poorly to radiotherapy. Furthermore, she presented with recurrence and metastatic disease a month after surgery. She was lost to follow-up clinic.
AB - Malignant melanoma of the vulva is a rare and aggressive tumour with dismal prognosis. It tends to recur and metastasize early. Surgical excision with or without regional lymph node dissection is still the treatment of choice with adjuvant therapy decided on a case by case. Furthermore, HIV infection has been associated with more aggressive disease. Herein we present a 45-year-old HIV-infected female patient on antiretroviral therapy who presented with vulval ulcer for one year. On examination, she had ulcerated nodule on the labia majora. Radiology showed vulvovaginal tumour without involvement of the adjacent organs. Malignant melanoma was confirmed on both the incisional biopsy and vulvectomy. She responded poorly to radiotherapy. Furthermore, she presented with recurrence and metastatic disease a month after surgery. She was lost to follow-up clinic.
KW - Case report
KW - HIV
KW - Malignant
KW - Metastasis
KW - Nodular melanoma
UR - http://www.scopus.com/inward/record.url?scp=85102892032&partnerID=8YFLogxK
U2 - 10.11604/pamj.2021.38.115.25864
DO - 10.11604/pamj.2021.38.115.25864
M3 - Article
C2 - 33912285
AN - SCOPUS:85102892032
SN - 1937-8688
VL - 38
JO - Pan African Medical Journal
JF - Pan African Medical Journal
M1 - 115
ER -