Management of Patients with Advanced Prostate Cancer. Report from the 2024 Advanced Prostate Cancer Consensus Conference (APCCC)

Silke Gillessen*, Fabio Turco, Ian D. Davis, Jason A. Efstathiou, Karim Fizazi, Nicholas D. James, Neal Shore, Eric Small, Matthew Smith, Christopher J. Sweeney, Bertrand Tombal, Thomas Zilli, Neeraj Agarwal, Emmanuel S. Antonarakis, Ana Aparicio, Andrew J. Armstrong, Diogo Assed Bastos, Gerhardt Attard, Karol Axcrona, Mouna AyadiHimisha Beltran, Anders Bjartell, Pierre Blanchard, Maria T. Bourlon, Alberto Briganti, Muhammad Bulbul, Consuelo Buttigliero, Orazio Caffo, Daniel Castellano, Elena Castro, Heather H. Cheng, Kim N. Chi, Caroline S. Clarke, Noel Clarke, Johann S. de Bono, Maria De Santis, Ignacio Duran, Eleni Efstathiou, Onyeanunam N. Ekeke, Tamer I.H. El Nahas, Louise Emmett, Stefano Fanti, Omolara A. Fatiregun, Felix Y. Feng, Peter C.C. Fong, Valerie Fonteyne, Nicola Fossati, Daniel J. George, Martin E. Gleave, Gwenaelle Gravis, Susan Halabi, Daniel Heinrich, Ken Herrmann, Michael S. Hofman, Thomas A. Hope, Lisa G. Horvath, Maha H.A. Hussain, Barbara Alicja Jereczek-Fossa, Robert J. Jones, Anthony M. Joshua, Ravindren Kanesvaran, Daniel Keizman, Raja B. Khauli, Gero Kramer, Stacy Loeb, Brandon A. Mahal, Fernando C. Maluf, Joaquin Mateo, David Matheson, Mika P. Matikainen, Ray McDermott, Rana R. McKay, Niven Mehra, Axel S. Merseburger, Alicia K. Morgans, Michael J. Morris, Hind Mrabti, Deborah Mukherji, Declan G. Murphy, Vedang Murthy, Shingai B.A. Mutambirwa, Paul L. Nguyen, William K. Oh, Piet Ost, Joe M. O'Sullivan, Anwar R. Padhani, Chris Parker, Darren M.C. Poon, Colin C. Pritchard, Danny M. Rabah, Dana Rathkopf, Robert E. Reiter, Raphaele Renard-Penna, Charles J. Ryan, Fred Saad, Juan Pablo Sade, Shahneen Sandhu, Oliver A. Sartor, Edward Schaeffer, Howard I. Scher, Nima Sharifi, Iwona A. Skoneczna, Howard R. Soule, Daniel E. Spratt, Sandy Srinivas, Cora N. Sternberg, Hiroyoshi Suzuki, Mary Ellen Taplin, Camilla Thellenberg-Karlsson, Derya Tilki, Levent N. Türkeri, Hiroji Uemura, Yüksel Ürün, Claire L. Vale, Neha Vapiwala, Jochen Walz, Kosj Yamoah, Dingwei Ye, Evan Y. Yu, Almudena Zapatero, Aurelius Omlin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background and objective: Innovations have improved outcomes in advanced prostate cancer (PC). Nonetheless, we continue to lack high-level evidence on a variety of topics that greatly impact daily practice. The 2024 Advanced Prostate Cancer Consensus Conference (APCCC) surveyed experts on key questions in clinical management in order to supplement evidence-based guidelines. Here we present voting results for questions from APCCC 2024. Methods: Before the conference, a panel of 120 international PC experts used a modified Delphi process to develop 183 multiple-choice consensus questions on eight different topics. Before the conference, these questions were administered via a web-based survey to the voting panel members (“panellists”). Key findings and limitations: Consensus was a priori defined as ≥75% agreement, with strong consensus defined as ≥90% agreement. The voting results show varying degrees of consensus, as discussed in this article and detailed in the Supplementary material. These findings do not include a formal literature review or meta-analysis. Conclusions and clinical implications: The voting results can help physicians and patients navigate controversial areas of clinical management for which high-level evidence is scant or conflicting. The findings can also help funders and policymakers in prioritising areas for future research. Diagnostic and treatment decisions should always be individualised on the basis of patient and cancer characteristics, and should incorporate current and emerging clinical evidence, guidelines, and logistic and economic factors. Enrolment in clinical trials is always strongly encouraged. Importantly, APCCC 2024 once again identified important gaps (areas of nonconsensus) that merit evaluation in specifically designed trials.

Original languageEnglish
JournalEuropean Urology
DOIs
Publication statusAccepted/In press - 2024
Externally publishedYes

Keywords

  • Adjuvant therapy
  • Biochemical recurrence
  • Bone protection
  • Genetics and genomics
  • Hormonal treatment
  • Next-generation imaging
  • Positron emission tomography
  • Prostate cancer
  • Prostate-specific membrane antigen
  • Salvage therapy

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