Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS-CoV-2 infection in South Africa: An International Network of Obstetric Survey Systems-based cohort study

Samantha Budhram; Valerie Vannevel; Tanita Botha; Lawrence Chauke; Shastra Bhoora; Gaynor M. Balie; Natalie Odell; Hennie Lombaard; Amy Wise; Chrysanthi Georgiou; Nondumiso Ngxola; Emma Wynne; Unati Mbewu; Mfundo Mabenge; Sibusiso Phinzi; Nontsikelelo Gubu-Ntaba; Gareth Goldman; Kay Tunkyi; Sudhir Prithipal; Keshree Naidoo; Santhi Venkatachalam; Terence Moodley; Sean Mould; Mzuvele Hlabisa; Logie Govender; Charlene Maistry; John P. Habineza; Priya Israel; Serantha Foolchand; Nomandla V. Tsibiyane; Mala Panday; Priya Soma-Pillay; Sumaiya Adam; Felicia Molokoane; Matthew S. Mojela; Elizabeth J. van Rensburg; Tshililo Mashamba; Mushi Matjila; Sue Fawcus; Ayesha Osman; Mareli Venter; Gregory Petro; Ahminah Fakier; Eduard Langenegger; Catherine A. Cluver; Adrie Bekker; Liesl de Waard; Chantal Stewart; Nnabuike C. Ngene; Ongombe Lunda; Sylvia N.Cebekhulu; Siva Moodley; Mama Asu Koranteng-Peprah; Emmanuel M.C. Ati; Salome Maswime; Laura M. Yates

doi:10.1002/ijgo.13917

Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS-CoV-2 infection in South Africa: An International Network of Obstetric Survey Systems-based cohort study

Samantha Budhram^*, Valerie Vannevel, Tanita Botha, Lawrence Chauke, Shastra Bhoora, Gaynor M. Balie, Natalie Odell, Hennie Lombaard, Amy Wise, Chrysanthi Georgiou, Nondumiso Ngxola, Emma Wynne, Unati Mbewu, Mfundo Mabenge, Sibusiso Phinzi, Nontsikelelo Gubu-Ntaba, Gareth Goldman, Kay Tunkyi, Sudhir Prithipal, Keshree NaidooSanthi Venkatachalam, Terence Moodley, Sean Mould, Mzuvele Hlabisa, Logie Govender, Charlene Maistry, John P. Habineza, Priya Israel, Serantha Foolchand, Nomandla V. Tsibiyane, Mala Panday, Priya Soma-Pillay, Sumaiya Adam, Felicia Molokoane, Matthew S. Mojela, Elizabeth J. van Rensburg, Tshililo Mashamba, Mushi Matjila, Sue Fawcus, Ayesha Osman, Mareli Venter, Gregory Petro, Ahminah Fakier, Eduard Langenegger, Catherine A. Cluver, Adrie Bekker, Liesl de Waard, Chantal Stewart, Nnabuike C. Ngene, Ongombe Lunda, Sylvia N.Cebekhulu, Siva Moodley, Mama Asu Koranteng-Peprah, Emmanuel M.C. Ati, Salome Maswime, Laura M. Yates

^*Corresponding author for this work

Obstetrics & Gynaecology

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Objective: To describe risk factors and outcomes of pregnant women infected with SARS-CoV-2 admitted to South African healthcare facilities. Methods: A population-based cohort study was conducted utilizing an amended International Obstetric Surveillance System protocol. Data on pregnant women with SARS-CoV-2 infection, hospitalized between April 14, 2020, and November 24, 2020, were analyzed. Results: A total of 36 hospitals submitted data on 673 infected hospitalized pregnant women; 217 (32.2%) were admitted for COVID-19 illness and 456 for other indications. There were 39 deaths with a case fatality rate of 6.3%: 32 (14.7%) deaths occurred in women admitted for COVID-19 illness compared to 7 (1.8%) in women admitted for other indications. Of the women, 106 (15.9%) required critical care. Maternal tuberculosis, but not HIV co-infection or other co-morbidities, was associated with admission for COVID-19 illness. Rates of cesarean delivery did not differ significantly between women admitted for COVID-19 and those admitted for other indications. There were 179 (35.4%) preterm births, 25 (4.7%) stillbirths, 12 (2.3%) neonatal deaths, and 162 (30.8%) neonatal admissions. Neonatal outcomes did not differ significantly from those of infected women admitted for other indications. Conclusion: The maternal mortality rate was high among women admitted with SARS-CoV-2 infection and higher in women admitted primarily for COVID-19 illness with tuberculosis being the only co-morbidity associated with admission.

Original language	English
Pages (from-to)	455-465
Number of pages	11
Journal	International Journal of Gynecology and Obstetrics
Volume	155
Issue number	3
DOIs	https://doi.org/10.1002/ijgo.13917
Publication status	Published - Dec 2021

Keywords

COVID-19
SARS-CoV-2
low- and middle-income country
perinatal
pregnancy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ijgo.13917

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Budhram, S., Vannevel, V., Botha, T., Chauke, L., Bhoora, S., Balie, G. M., Odell, N., Lombaard, H., Wise, A., Georgiou, C., Ngxola, N., Wynne, E., Mbewu, U., Mabenge, M., Phinzi, S., Gubu-Ntaba, N., Goldman, G., Tunkyi, K., Prithipal, S., ... Yates, L. M. (2021). Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS-CoV-2 infection in South Africa: An International Network of Obstetric Survey Systems-based cohort study. International Journal of Gynecology and Obstetrics, 155(3), 455-465. https://doi.org/10.1002/ijgo.13917

@article{12311f1aff9144f7b38d38d750944be7,

title = "Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS-CoV-2 infection in South Africa: An International Network of Obstetric Survey Systems-based cohort study",

abstract = "Objective: To describe risk factors and outcomes of pregnant women infected with SARS-CoV-2 admitted to South African healthcare facilities. Methods: A population-based cohort study was conducted utilizing an amended International Obstetric Surveillance System protocol. Data on pregnant women with SARS-CoV-2 infection, hospitalized between April 14, 2020, and November 24, 2020, were analyzed. Results: A total of 36 hospitals submitted data on 673 infected hospitalized pregnant women; 217 (32.2%) were admitted for COVID-19 illness and 456 for other indications. There were 39 deaths with a case fatality rate of 6.3%: 32 (14.7%) deaths occurred in women admitted for COVID-19 illness compared to 7 (1.8%) in women admitted for other indications. Of the women, 106 (15.9%) required critical care. Maternal tuberculosis, but not HIV co-infection or other co-morbidities, was associated with admission for COVID-19 illness. Rates of cesarean delivery did not differ significantly between women admitted for COVID-19 and those admitted for other indications. There were 179 (35.4%) preterm births, 25 (4.7%) stillbirths, 12 (2.3%) neonatal deaths, and 162 (30.8%) neonatal admissions. Neonatal outcomes did not differ significantly from those of infected women admitted for other indications. Conclusion: The maternal mortality rate was high among women admitted with SARS-CoV-2 infection and higher in women admitted primarily for COVID-19 illness with tuberculosis being the only co-morbidity associated with admission.",

keywords = "COVID-19, SARS-CoV-2, low- and middle-income country, perinatal, pregnancy",

author = "Samantha Budhram and Valerie Vannevel and Tanita Botha and Lawrence Chauke and Shastra Bhoora and Balie, {Gaynor M.} and Natalie Odell and Hennie Lombaard and Amy Wise and Chrysanthi Georgiou and Nondumiso Ngxola and Emma Wynne and Unati Mbewu and Mfundo Mabenge and Sibusiso Phinzi and Nontsikelelo Gubu-Ntaba and Gareth Goldman and Kay Tunkyi and Sudhir Prithipal and Keshree Naidoo and Santhi Venkatachalam and Terence Moodley and Sean Mould and Mzuvele Hlabisa and Logie Govender and Charlene Maistry and Habineza, {John P.} and Priya Israel and Serantha Foolchand and Tsibiyane, {Nomandla V.} and Mala Panday and Priya Soma-Pillay and Sumaiya Adam and Felicia Molokoane and Mojela, {Matthew S.} and {van Rensburg}, {Elizabeth J.} and Tshililo Mashamba and Mushi Matjila and Sue Fawcus and Ayesha Osman and Mareli Venter and Gregory Petro and Ahminah Fakier and Eduard Langenegger and Cluver, {Catherine A.} and Adrie Bekker and {de Waard}, Liesl and Chantal Stewart and Ngene, {Nnabuike C.} and Ongombe Lunda and Sylvia N.Cebekhulu and Siva Moodley and Koranteng-Peprah, {Mama Asu} and Ati, {Emmanuel M.C.} and Salome Maswime and Yates, {Laura M.}",

note = "Publisher Copyright: {\textcopyright} 2021 International Federation of Gynecology and Obstetrics.",

year = "2021",

month = dec,

doi = "10.1002/ijgo.13917",

language = "English",

volume = "155",

pages = "455--465",

journal = "International Journal of Gynecology and Obstetrics",

issn = "0020-7292",

publisher = "John Wiley and Sons Ltd",

number = "3",

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Budhram, S, Vannevel, V, Botha, T, Chauke, L, Bhoora, S, Balie, GM, Odell, N, Lombaard, H, Wise, A, Georgiou, C, Ngxola, N, Wynne, E, Mbewu, U, Mabenge, M, Phinzi, S, Gubu-Ntaba, N, Goldman, G, Tunkyi, K, Prithipal, S, Naidoo, K, Venkatachalam, S, Moodley, T, Mould, S, Hlabisa, M, Govender, L, Maistry, C, Habineza, JP, Israel, P, Foolchand, S, Tsibiyane, NV, Panday, M, Soma-Pillay, P, Adam, S, Molokoane, F, Mojela, MS, van Rensburg, EJ, Mashamba, T, Matjila, M, Fawcus, S, Osman, A, Venter, M, Petro, G, Fakier, A, Langenegger, E, Cluver, CA, Bekker, A, de Waard, L, Stewart, C, Ngene, NC, Lunda, O, N.Cebekhulu, S, Moodley, S, Koranteng-Peprah, MA, Ati, EMC, Maswime, S & Yates, LM 2021, 'Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS-CoV-2 infection in South Africa: An International Network of Obstetric Survey Systems-based cohort study', International Journal of Gynecology and Obstetrics, vol. 155, no. 3, pp. 455-465. https://doi.org/10.1002/ijgo.13917

Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS-CoV-2 infection in South Africa: An International Network of Obstetric Survey Systems-based cohort study. / Budhram, Samantha; Vannevel, Valerie; Botha, Tanita et al.
In: International Journal of Gynecology and Obstetrics, Vol. 155, No. 3, 12.2021, p. 455-465.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS-CoV-2 infection in South Africa

T2 - An International Network of Obstetric Survey Systems-based cohort study

AU - Budhram, Samantha

AU - Vannevel, Valerie

AU - Botha, Tanita

AU - Chauke, Lawrence

AU - Bhoora, Shastra

AU - Balie, Gaynor M.

AU - Odell, Natalie

AU - Lombaard, Hennie

AU - Wise, Amy

AU - Georgiou, Chrysanthi

AU - Ngxola, Nondumiso

AU - Wynne, Emma

AU - Mbewu, Unati

AU - Mabenge, Mfundo

AU - Phinzi, Sibusiso

AU - Gubu-Ntaba, Nontsikelelo

AU - Goldman, Gareth

AU - Tunkyi, Kay

AU - Prithipal, Sudhir

AU - Naidoo, Keshree

AU - Venkatachalam, Santhi

AU - Moodley, Terence

AU - Mould, Sean

AU - Hlabisa, Mzuvele

AU - Govender, Logie

AU - Maistry, Charlene

AU - Habineza, John P.

AU - Israel, Priya

AU - Foolchand, Serantha

AU - Tsibiyane, Nomandla V.

AU - Panday, Mala

AU - Soma-Pillay, Priya

AU - Adam, Sumaiya

AU - Molokoane, Felicia

AU - Mojela, Matthew S.

AU - van Rensburg, Elizabeth J.

AU - Mashamba, Tshililo

AU - Matjila, Mushi

AU - Fawcus, Sue

AU - Osman, Ayesha

AU - Venter, Mareli

AU - Petro, Gregory

AU - Fakier, Ahminah

AU - Langenegger, Eduard

AU - Cluver, Catherine A.

AU - Bekker, Adrie

AU - de Waard, Liesl

AU - Stewart, Chantal

AU - Ngene, Nnabuike C.

AU - Lunda, Ongombe

AU - N.Cebekhulu, Sylvia

AU - Moodley, Siva

AU - Koranteng-Peprah, Mama Asu

AU - Ati, Emmanuel M.C.

AU - Maswime, Salome

AU - Yates, Laura M.

PY - 2021/12

Y1 - 2021/12

N2 - Objective: To describe risk factors and outcomes of pregnant women infected with SARS-CoV-2 admitted to South African healthcare facilities. Methods: A population-based cohort study was conducted utilizing an amended International Obstetric Surveillance System protocol. Data on pregnant women with SARS-CoV-2 infection, hospitalized between April 14, 2020, and November 24, 2020, were analyzed. Results: A total of 36 hospitals submitted data on 673 infected hospitalized pregnant women; 217 (32.2%) were admitted for COVID-19 illness and 456 for other indications. There were 39 deaths with a case fatality rate of 6.3%: 32 (14.7%) deaths occurred in women admitted for COVID-19 illness compared to 7 (1.8%) in women admitted for other indications. Of the women, 106 (15.9%) required critical care. Maternal tuberculosis, but not HIV co-infection or other co-morbidities, was associated with admission for COVID-19 illness. Rates of cesarean delivery did not differ significantly between women admitted for COVID-19 and those admitted for other indications. There were 179 (35.4%) preterm births, 25 (4.7%) stillbirths, 12 (2.3%) neonatal deaths, and 162 (30.8%) neonatal admissions. Neonatal outcomes did not differ significantly from those of infected women admitted for other indications. Conclusion: The maternal mortality rate was high among women admitted with SARS-CoV-2 infection and higher in women admitted primarily for COVID-19 illness with tuberculosis being the only co-morbidity associated with admission.

AB - Objective: To describe risk factors and outcomes of pregnant women infected with SARS-CoV-2 admitted to South African healthcare facilities. Methods: A population-based cohort study was conducted utilizing an amended International Obstetric Surveillance System protocol. Data on pregnant women with SARS-CoV-2 infection, hospitalized between April 14, 2020, and November 24, 2020, were analyzed. Results: A total of 36 hospitals submitted data on 673 infected hospitalized pregnant women; 217 (32.2%) were admitted for COVID-19 illness and 456 for other indications. There were 39 deaths with a case fatality rate of 6.3%: 32 (14.7%) deaths occurred in women admitted for COVID-19 illness compared to 7 (1.8%) in women admitted for other indications. Of the women, 106 (15.9%) required critical care. Maternal tuberculosis, but not HIV co-infection or other co-morbidities, was associated with admission for COVID-19 illness. Rates of cesarean delivery did not differ significantly between women admitted for COVID-19 and those admitted for other indications. There were 179 (35.4%) preterm births, 25 (4.7%) stillbirths, 12 (2.3%) neonatal deaths, and 162 (30.8%) neonatal admissions. Neonatal outcomes did not differ significantly from those of infected women admitted for other indications. Conclusion: The maternal mortality rate was high among women admitted with SARS-CoV-2 infection and higher in women admitted primarily for COVID-19 illness with tuberculosis being the only co-morbidity associated with admission.

KW - COVID-19

KW - SARS-CoV-2

KW - low- and middle-income country

KW - perinatal

KW - pregnancy

UR - http://www.scopus.com/inward/record.url?scp=85114933685&partnerID=8YFLogxK

U2 - 10.1002/ijgo.13917

DO - 10.1002/ijgo.13917

M3 - Article

C2 - 34499750

AN - SCOPUS:85114933685

SN - 0020-7292

VL - 155

SP - 455

EP - 465

JO - International Journal of Gynecology and Obstetrics

JF - International Journal of Gynecology and Obstetrics

IS - 3

ER -

Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS-CoV-2 infection in South Africa: An International Network of Obstetric Survey Systems-based cohort study

Abstract

Keywords

UN SDGs

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