Mediastinal cryptococcoma as part of disseminated cryptococcosis in HIV-negative pregnant woman with Myasthenia Gravis: Autopsy case report

Bianca Ponnamma Samy; Nosipho Maria Thobakgale; Moshawa Calvin Khaba

doi:10.1016/j.mmcr.2025.100726

Mediastinal cryptococcoma as part of disseminated cryptococcosis in HIV-negative pregnant woman with Myasthenia Gravis: Autopsy case report

Bianca Ponnamma Samy
, Nosipho Maria Thobakgale
, Moshawa Calvin Khaba^*

^*Corresponding author for this work

Anatomical Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

Cryptococcosis is a fungal infection commonly found in immunocompromised individuals, but it can also affect immunocompetent individuals. A pregnant woman with myasthenia gravis, HIV-negative, died after a diagnosis of tuberculosis. An autopsy revealed a mediastinal mass and organ involvement, indicating a disseminated cryptococcal infection. This case highlights the importance of maintaining a high index of suspicion for cryptococcal infection in immunosuppressed individuals, even without HIV/AIDS. Early detection is achieved by measuring serum cryptococcal antigen.

Original language	English
Article number	100726
Journal	Medical Mycology Case Reports
Volume	49
DOIs	https://doi.org/10.1016/j.mmcr.2025.100726
Publication status	Published - Sept 2025

Keywords

Autopsy
Cryptococcosis
HIV/AIDS
Myasthenia gravis
Pregnancy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mmcr.2025.100726

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title = "Mediastinal cryptococcoma as part of disseminated cryptococcosis in HIV-negative pregnant woman with Myasthenia Gravis: Autopsy case report",

abstract = "Cryptococcosis is a fungal infection commonly found in immunocompromised individuals, but it can also affect immunocompetent individuals. A pregnant woman with myasthenia gravis, HIV-negative, died after a diagnosis of tuberculosis. An autopsy revealed a mediastinal mass and organ involvement, indicating a disseminated cryptococcal infection. This case highlights the importance of maintaining a high index of suspicion for cryptococcal infection in immunosuppressed individuals, even without HIV/AIDS. Early detection is achieved by measuring serum cryptococcal antigen.",

keywords = "Autopsy, Cryptococcosis, HIV/AIDS, Myasthenia gravis, Pregnancy",

author = "Samy, \{Bianca Ponnamma\} and Thobakgale, \{Nosipho Maria\} and Khaba, \{Moshawa Calvin\}",

note = "Publisher Copyright: {\textcopyright} 2025",

year = "2025",

month = sep,

doi = "10.1016/j.mmcr.2025.100726",

language = "English",

volume = "49",

journal = "Medical Mycology Case Reports",

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TY - JOUR

T1 - Mediastinal cryptococcoma as part of disseminated cryptococcosis in HIV-negative pregnant woman with Myasthenia Gravis

T2 - Autopsy case report

AU - Samy, Bianca Ponnamma

AU - Thobakgale, Nosipho Maria

AU - Khaba, Moshawa Calvin

PY - 2025/9

Y1 - 2025/9

N2 - Cryptococcosis is a fungal infection commonly found in immunocompromised individuals, but it can also affect immunocompetent individuals. A pregnant woman with myasthenia gravis, HIV-negative, died after a diagnosis of tuberculosis. An autopsy revealed a mediastinal mass and organ involvement, indicating a disseminated cryptococcal infection. This case highlights the importance of maintaining a high index of suspicion for cryptococcal infection in immunosuppressed individuals, even without HIV/AIDS. Early detection is achieved by measuring serum cryptococcal antigen.

AB - Cryptococcosis is a fungal infection commonly found in immunocompromised individuals, but it can also affect immunocompetent individuals. A pregnant woman with myasthenia gravis, HIV-negative, died after a diagnosis of tuberculosis. An autopsy revealed a mediastinal mass and organ involvement, indicating a disseminated cryptococcal infection. This case highlights the importance of maintaining a high index of suspicion for cryptococcal infection in immunosuppressed individuals, even without HIV/AIDS. Early detection is achieved by measuring serum cryptococcal antigen.

KW - Autopsy

KW - Cryptococcosis

KW - HIV/AIDS

KW - Myasthenia gravis

KW - Pregnancy

UR - https://www.scopus.com/pages/publications/105013654549

U2 - 10.1016/j.mmcr.2025.100726

DO - 10.1016/j.mmcr.2025.100726

M3 - Article

C2 - 40893460

AN - SCOPUS:105013654549

SN - 2211-7539

VL - 49

JO - Medical Mycology Case Reports

JF - Medical Mycology Case Reports

M1 - 100726

ER -

Mediastinal cryptococcoma as part of disseminated cryptococcosis in HIV-negative pregnant woman with Myasthenia Gravis: Autopsy case report

Abstract

Keywords

UN SDGs

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