Modelling the efficacy of antiretroviral treatment in HIV patients: Case of Dr George Mukhari academic hospital in Tshwane, Gauteng province, South Africa

Madimetja Marcus Motshwane, Solly Matshonisa Seeletse*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

This paper used survival analysis to evaluate the efficacy of antiretroviral (ARV) treatment in HIV patients and also to determine if ARVs reduces the risk of HIV/AIDS. Secondary data were collected from files archived in Tshepang Clinic in Dr George Mukhari Academic Hospital in Tshwane, Gauteng Province of South Africa. Survival time was regressed on influential variables that affect survival. The statistical data analysis was conducted using STATA. Both descriptive and inferential statistics were used in the analysis of data. Of the 318 patients tested, 292 (92%) were alive after treatment and 26 (8%) had died. Survival time was regressed on influential variables (gender, age, education level, marital status, township, CD4 count and viral load) affecting survival. The epidemiological measure of effect was the hazard ratio. At the 5% level of significance, significant hazard ratios were characterized by hazard ratios that are significantly different from "1", p<0.05 and 95% Confidence Interval (CI). The combination of Regimen 1 and 2 of ARVs had a positive and significant impact on the lives of patients around the hospital's jurisdiction. The Cox Proportional Hazards Model was identified as the most suitable for the Tshepang data. An equation and models are provided.

Original languageEnglish
Article number5
Pages (from-to)924-931
Number of pages8
JournalAmerican Journal of Applied Sciences
Volume13
Issue number8
DOIs
Publication statusPublished - 17 Aug 2016

Keywords

  • Log rank
  • Regimen
  • Survival
  • Treatment efficacy

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