Molecular Characterization of rotavirus strains circulating in Oman in 2005

Said Al Baqlani; Ina Peenze; John Dewar; Zainab Al Lawati; Lindsey Pearson; Varghese Rupa; Charles Mothokoa; Salah Al Awaidy; Suleiman Al Busaidy; A. Duncan Steele

doi:10.1086/653582

Molecular Characterization of rotavirus strains circulating in Oman in 2005

Said Al Baqlani
, Ina Peenze
, John Dewar
, Zainab Al Lawati
, Lindsey Pearson
, Varghese Rupa
, Charles Mothokoa
, Salah Al Awaidy
, Suleiman Al Busaidy
, A. Duncan Steele

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Limited genotyping data are available for rotavirus strains in the Middle East. In this study, we investigated the molecular epidemiology of human rotavirus strains circulating in the Sultanate of Oman during 2005. Rotavirus was detected in 178 (57.4%) of 310 of the diarrheal stools of young children <5 years admitted to hospitals and outpatients clinics. Polyacrylamide gel electrophoresis demonstrated the cocirculation of 8 strains, although 2 strains predominated across the Sultanate. Genotyping revealed the presence of human rotavirus strains of types G1P[8], G2P[4], and G3P[8]. Several strains exhibited unusual combinations of G and P genotypes and RNA electropherotypes, indicating the likelihood of natural reassortment events occurring with a high frequency. In addition, the unusual P[10] genotype was identified among the rotavirus strains, in combination with the G1 type.

Original language	English
Pages (from-to)	S258-S262
Journal	Journal of Infectious Diseases
Volume	202
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1086/653582
Publication status	Published - 1 Sept 2010
Externally published	Yes

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SDG 3 Good Health and Well-being

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title = "Molecular Characterization of rotavirus strains circulating in Oman in 2005",

abstract = "Limited genotyping data are available for rotavirus strains in the Middle East. In this study, we investigated the molecular epidemiology of human rotavirus strains circulating in the Sultanate of Oman during 2005. Rotavirus was detected in 178 (57.4\%) of 310 of the diarrheal stools of young children <5 years admitted to hospitals and outpatients clinics. Polyacrylamide gel electrophoresis demonstrated the cocirculation of 8 strains, although 2 strains predominated across the Sultanate. Genotyping revealed the presence of human rotavirus strains of types G1P[8], G2P[4], and G3P[8]. Several strains exhibited unusual combinations of G and P genotypes and RNA electropherotypes, indicating the likelihood of natural reassortment events occurring with a high frequency. In addition, the unusual P[10] genotype was identified among the rotavirus strains, in combination with the G1 type.",

author = "Baqlani, \{Said Al\} and Ina Peenze and John Dewar and Lawati, \{Zainab Al\} and Lindsey Pearson and Varghese Rupa and Charles Mothokoa and Awaidy, \{Salah Al\} and Busaidy, \{Suleiman Al\} and Steele, \{A. Duncan\}",

note = "Funding Information: Financial support: World Health Organization (grant V27/181/113), Rotavirus Vaccine Program (grant GAV.1142-01-07211-SPS), Norwegian Council for Higher Education (grant PRO 48/2002), Ministry of Health, Oman, and Medical Research Council of South Africa. Funding Information: Supplement sponsorship: This article is part of a supplement entitled “Rotavirus Infection In Africa: Epidemiology, Burden of Disease, and Strain Diversity,” which was prepared as a project of the Rotavirus Vaccine Program, a partnership among PATH, the World Health Organization, and the US Centers for Disease Control and Prevention, and was funded in full or in part by the GAVI Alliance.",

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doi = "10.1086/653582",

language = "English",

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AU - Baqlani, Said Al

AU - Peenze, Ina

AU - Dewar, John

AU - Lawati, Zainab Al

AU - Pearson, Lindsey

AU - Rupa, Varghese

AU - Mothokoa, Charles

AU - Awaidy, Salah Al

AU - Busaidy, Suleiman Al

AU - Steele, A. Duncan

N1 - Funding Information: Financial support: World Health Organization (grant V27/181/113), Rotavirus Vaccine Program (grant GAV.1142-01-07211-SPS), Norwegian Council for Higher Education (grant PRO 48/2002), Ministry of Health, Oman, and Medical Research Council of South Africa. Funding Information: Supplement sponsorship: This article is part of a supplement entitled “Rotavirus Infection In Africa: Epidemiology, Burden of Disease, and Strain Diversity,” which was prepared as a project of the Rotavirus Vaccine Program, a partnership among PATH, the World Health Organization, and the US Centers for Disease Control and Prevention, and was funded in full or in part by the GAVI Alliance.

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N2 - Limited genotyping data are available for rotavirus strains in the Middle East. In this study, we investigated the molecular epidemiology of human rotavirus strains circulating in the Sultanate of Oman during 2005. Rotavirus was detected in 178 (57.4%) of 310 of the diarrheal stools of young children <5 years admitted to hospitals and outpatients clinics. Polyacrylamide gel electrophoresis demonstrated the cocirculation of 8 strains, although 2 strains predominated across the Sultanate. Genotyping revealed the presence of human rotavirus strains of types G1P[8], G2P[4], and G3P[8]. Several strains exhibited unusual combinations of G and P genotypes and RNA electropherotypes, indicating the likelihood of natural reassortment events occurring with a high frequency. In addition, the unusual P[10] genotype was identified among the rotavirus strains, in combination with the G1 type.

AB - Limited genotyping data are available for rotavirus strains in the Middle East. In this study, we investigated the molecular epidemiology of human rotavirus strains circulating in the Sultanate of Oman during 2005. Rotavirus was detected in 178 (57.4%) of 310 of the diarrheal stools of young children <5 years admitted to hospitals and outpatients clinics. Polyacrylamide gel electrophoresis demonstrated the cocirculation of 8 strains, although 2 strains predominated across the Sultanate. Genotyping revealed the presence of human rotavirus strains of types G1P[8], G2P[4], and G3P[8]. Several strains exhibited unusual combinations of G and P genotypes and RNA electropherotypes, indicating the likelihood of natural reassortment events occurring with a high frequency. In addition, the unusual P[10] genotype was identified among the rotavirus strains, in combination with the G1 type.

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JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

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ER -

Molecular Characterization of rotavirus strains circulating in Oman in 2005

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