Morbidity and mortality due to shigella and enterotoxigenic Escherichia coli diarrhoea: the Global Burden of Disease Study 1990–2016

Ibrahim A. Khalil, Christopher Troeger, Brigette F. Blacker, Puja C. Rao, Alexandria Brown, Deborah E. Atherly, Thomas G. Brewer, Cyril M. Engmann, Eric R. Houpt, Gagandeep Kang, Karen L. Kotloff, Myron M. Levine, Stephen P. Luby, Calman A. MacLennan, William K. Pan, Patricia B. Pavlinac, James A. Platts-Mills, Firdausi Qadri, Mark S. Riddle, Edward T. RyanDavid A. Shoultz, A. Duncan Steele, Judd L. Walson, John W. Sanders, Ali H. Mokdad, Christopher J.L. Murray, Simon I. Hay, Robert C. Reiner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

388 Citations (Scopus)


Background: Shigella and enterotoxigenic Escherichia coli (ETEC) are bacterial pathogens that are frequently associated with diarrhoeal disease, and are a significant cause of mortality and morbidity worldwide. The Global Burden of Diseases, Injuries, and Risk Factors study 2016 (GBD 2016) is a systematic, scientific effort to quantify the morbidity and mortality due to over 300 causes of death and disability. We aimed to analyse the global burden of shigella and ETEC diarrhoea according to age, sex, geography, and year from 1990 to 2016. Methods: We modelled shigella and ETEC-related mortality using a Bayesian hierarchical modelling platform that evaluates a wide range of covariates and model types on the basis of vital registration and verbal autopsy data. We used a compartmental meta-regression tool to model the incidence of shigella and ETEC, which enforces an association between incidence, prevalence, and remission on the basis of scientific literature, population representative surveys, and health-care data. We calculated 95% uncertainty intervals (UIs) for the point estimates. Findings: Shigella was the second leading cause of diarrhoeal mortality in 2016 among all ages, accounting for 212 438 deaths (95% UI 136 979–326 913) and about 13·2% (9·2–17·4) of all diarrhoea deaths. Shigella was responsible for 63 713 deaths (41 191–93 611) among children younger than 5 years and was frequently associated with diarrhoea across all adult age groups, increasing in elderly people, with broad geographical distribution. ETEC was the eighth leading cause of diarrhoea mortality in 2016 among all age groups, accounting for 51 186 deaths (26 757–83 064) and about 3·2% (1·8–4·7) of diarrhoea deaths. ETEC was responsible for about 4·2% (2·2–6·8) of diarrhoea deaths in children younger than 5 years. Interpretation: The health burden of bacterial diarrhoeal pathogens is difficult to estimate. Despite existing prevention and treatment options, they remain a major cause of morbidity and mortality globally. Additional emphasis by public health officials is needed on a reduction in disease due to shigella and ETEC to reduce disease burden. Funding: Bill & Melinda Gates Foundation.

Original languageEnglish
Pages (from-to)1229-1240
Number of pages12
JournalThe Lancet Infectious Diseases
Issue number11
Publication statusPublished - Nov 2018
Externally publishedYes


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