TY - JOUR
T1 - Multidrug Resistant Group B Streptococcus Isolates from Pregnant Women in Delta State, Nigeria
AU - Egbule, Olivia Sochi
AU - Enwa, Oghenemaro Felix
AU - Omenogor, Patricia Konye
AU - Odum, Edward Ikenna
AU - Iweriebor, Benson Chucks
AU - Obi, C. L.
N1 - Publisher Copyright:
© 2024 Olivia Sochi Egbule et al.
PY - 2024
Y1 - 2024
N2 - Background and Objective: Group B Streptococci (GBS) are globally recognized as a major risk factor for neonatal infections and various obstetric complications. More so, biofilm formation has been suggested to be important for GBS pathogenesis. The aim of this study was to determine the prevalence and antibiotic susceptibility pattern of GBS among pregnant women and their capacity to form biofilm. Materials and Methods: A total of 87 pregnant women at 34 to 37 weeks’ gestation aged 17-45 years were recruited from 3 healthcare centres in Delta State, Nigeria. Cultures for the isolation of GBS were carried out using recto-vaginal swabs, according to standard microbiological methods. All strains isolated were used for susceptibility tests to various antibiotics as recommended by CLSI using the disk-diffusion method. Results: The overall prevalence of GBS colonization among pregnant women was 43.6% (38/87). The <30 age group had the highest rate of GBS colonization. Resistance to erythromycin and vancomycin was 48.2 and 66.4%, respectively. The fluoroquinolones had the lowest resistant rates with no isolate showing resistance to ofloxacin. Multidrug resistance (MDR) (>3 drug classes) was detected in 73.7% (28/38) of the GBS isolates. All GBS isolated in this study were either strong, moderate or weak biofilm producers. However, most 28 (73.7%) were strong biofilm producers. Resistance of GBS isolates to erythromycin and vancomycin, drugs used for treating GBS infection was high. Conclusion: This suggested the importance of testing antimicrobial susceptibilities in GBS colonized pregnant women in order to guide antibiotic therapy and minimize newborn infection and co-morbidity.
AB - Background and Objective: Group B Streptococci (GBS) are globally recognized as a major risk factor for neonatal infections and various obstetric complications. More so, biofilm formation has been suggested to be important for GBS pathogenesis. The aim of this study was to determine the prevalence and antibiotic susceptibility pattern of GBS among pregnant women and their capacity to form biofilm. Materials and Methods: A total of 87 pregnant women at 34 to 37 weeks’ gestation aged 17-45 years were recruited from 3 healthcare centres in Delta State, Nigeria. Cultures for the isolation of GBS were carried out using recto-vaginal swabs, according to standard microbiological methods. All strains isolated were used for susceptibility tests to various antibiotics as recommended by CLSI using the disk-diffusion method. Results: The overall prevalence of GBS colonization among pregnant women was 43.6% (38/87). The <30 age group had the highest rate of GBS colonization. Resistance to erythromycin and vancomycin was 48.2 and 66.4%, respectively. The fluoroquinolones had the lowest resistant rates with no isolate showing resistance to ofloxacin. Multidrug resistance (MDR) (>3 drug classes) was detected in 73.7% (28/38) of the GBS isolates. All GBS isolated in this study were either strong, moderate or weak biofilm producers. However, most 28 (73.7%) were strong biofilm producers. Resistance of GBS isolates to erythromycin and vancomycin, drugs used for treating GBS infection was high. Conclusion: This suggested the importance of testing antimicrobial susceptibilities in GBS colonized pregnant women in order to guide antibiotic therapy and minimize newborn infection and co-morbidity.
KW - Group B Streptococci
KW - biofilm formation
KW - multidrug resistance
KW - neonatal sepsis
KW - pathogenesis
KW - pregnant women
UR - http://www.scopus.com/inward/record.url?scp=85205265403&partnerID=8YFLogxK
U2 - 10.3923/pjbs.2024.447.454
DO - 10.3923/pjbs.2024.447.454
M3 - Article
AN - SCOPUS:85205265403
SN - 1028-8880
VL - 27
SP - 447
EP - 454
JO - Pakistan Journal of Biological Sciences
JF - Pakistan Journal of Biological Sciences
IS - 9
ER -