Nanofibrous Scaffolds for Diabetic Wound Healing

Anna Yusuf Aliyu, Oluwatoyin A. Adeleke*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)

Abstract

Chronic wounds are one of the secondary health complications that develop in individuals who have poorly managed diabetes mellitus. This is often associated with delays in the wound healing process, resulting from long-term uncontrolled blood glucose levels. As such, an appropriate therapeutic approach would be maintaining blood glucose concentration within normal ranges, but this can be quite challenging to achieve. Consequently, diabetic ulcers usually require special medical care to prevent complications such as sepsis, amputation, and deformities, which often develop in these patients. Although several conventional wound dressings, such as hydrogels, gauze, films, and foams, are employed in the treatment of such chronic wounds, nanofibrous scaffolds have gained the attention of researchers because of their flexibility, ability to load a variety of bioactive compounds as single entities or combinations, and large surface area to volume ratio, which provides a biomimetic environment for cell proliferation relative to conventional dressings. Here, we present the current trends on the versatility of nanofibrous scaffolds as novel platforms for the incorporation of bioactive agents suitable for the enhancement of diabetic wound healing.

Original languageEnglish
Article number986
JournalPharmaceutics
Volume15
Issue number3
DOIs
Publication statusPublished - Mar 2023
Externally publishedYes

Keywords

  • antibiotics
  • diabetes
  • diabetic wound
  • electrospinning
  • nanofibrous scaffolds
  • phase separation
  • phytoconstituents
  • polymeric biomaterials
  • self-assembly
  • skin regeneration
  • tissue engineering
  • wound dressings
  • wound healing

Fingerprint

Dive into the research topics of 'Nanofibrous Scaffolds for Diabetic Wound Healing'. Together they form a unique fingerprint.

Cite this