Nanotheranostic applications in the detection and treatment of cervical cancer

Jubilee Andrew, Waniwa Amuchilani, Larry L. Mweetwa, Swali V. Fundafunda, Madan S. Poka, Bwalya A. Witika

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Cervical cancer is one of the major gynecological cancers that have a tremendous impact on female health and quality of life, and it has become a major cause of death in women worldwide. Cervical cancer is more prevalent in developing countries, where access to imaging facilities is limited and the uptake of cervical cancer screening is low due to several barriers, and by the time the cancer is diagnosed, it would have been at an advanced stage. Detecting the disease at an earlier stage reduces progression to other organs of the body. Concurrent chemotherapy and radiation therapy is the most common treatment available for cervical cancer globally, but the challenge is sparing adjacent healthy tissues from exposure to these ablating agents. Further explorations for novel cervical cancer diagnosis and therapy strategies are of utmost importance to reduce mortality and improve patient prognosis. In this review, we discuss the current approaches to cervical cancer diagnosis and treatment modalities available and explore the application of nanotheranostics in detecting and treating cervical cancer. The ability of nanoparticles to be customized to develop theranostic properties and the possibility of tailoring the agents for targeted drug delivery is a positive strategy for improving cervical cancer management.

Original languageEnglish
Title of host publicationNanotechnology Principles in Drug Targeting and Diagnosis
PublisherElsevier
Pages413-430
Number of pages18
ISBN (Electronic)9780323917636
ISBN (Print)9780323983488
DOIs
Publication statusPublished - 1 Jan 2023

Keywords

  • Cervical cancer
  • chemotherapy
  • nanotheranostics
  • nuclear medicine
  • radiation therapy
  • radiopharmaceuticals

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