Neonatal intrahepatocellular lipid

E. L. Thomas; S. Uthaya; V. Vasu; J. P. McCarthy; P. McEwan; G. Hamilton; J. D. Bell; Neena Modi

Neonatal intrahepatocellular lipid

E. L. Thomas, S. Uthaya, V. Vasu, J. P. McCarthy, P. McEwan, G. Hamilton, J. D. Bell, Neena Modi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

There is increasing evidence that preterm birth is a risk factor for the development of adiposity associated disease, although the pathophysiological basis is unclear. We have previously shown that preterm infants have increased internal abdominal (visceral) adiposity by term. In adults increased internal adiposity is associated with elevated intrahepatocellular lipid (IHCL). We measured IHCL using ¹H NMR spectroscopy in 26 infants (eight healthy preterm-at-term and 18 term-born) and compared values with a reference group of 32 adults. There was no significant difference between adult and term-born IHCL content. In preterm-at-term infants IHCL was significantly elevated when compared with term-born infants and with adults (IHCL CH₂/water median (interquartile range): preterm 1.69 (1.04-3.53), term 0.21 (0-0.54) and adult 0.55 (0.08-1.57).

Original language	English
Pages (from-to)	f382-f383
Journal	Archives of Disease in Childhood: Fetal and Neonatal Edition
Volume	93
Issue number	5
Publication status	Published - Sept 2008
Externally published	Yes

Cite this

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title = "Neonatal intrahepatocellular lipid",

abstract = "There is increasing evidence that preterm birth is a risk factor for the development of adiposity associated disease, although the pathophysiological basis is unclear. We have previously shown that preterm infants have increased internal abdominal (visceral) adiposity by term. In adults increased internal adiposity is associated with elevated intrahepatocellular lipid (IHCL). We measured IHCL using 1H NMR spectroscopy in 26 infants (eight healthy preterm-at-term and 18 term-born) and compared values with a reference group of 32 adults. There was no significant difference between adult and term-born IHCL content. In preterm-at-term infants IHCL was significantly elevated when compared with term-born infants and with adults (IHCL CH2/water median (interquartile range): preterm 1.69 (1.04-3.53), term 0.21 (0-0.54) and adult 0.55 (0.08-1.57).",

author = "Thomas, {E. L.} and S. Uthaya and V. Vasu and McCarthy, {J. P.} and P. McEwan and G. Hamilton and Bell, {J. D.} and Neena Modi",

year = "2008",

month = sep,

language = "English",

volume = "93",

pages = "f382--f383",

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number = "5",

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TY - JOUR

T1 - Neonatal intrahepatocellular lipid

AU - Thomas, E. L.

AU - Uthaya, S.

AU - Vasu, V.

AU - McCarthy, J. P.

AU - McEwan, P.

AU - Hamilton, G.

AU - Bell, J. D.

AU - Modi, Neena

PY - 2008/9

Y1 - 2008/9

N2 - There is increasing evidence that preterm birth is a risk factor for the development of adiposity associated disease, although the pathophysiological basis is unclear. We have previously shown that preterm infants have increased internal abdominal (visceral) adiposity by term. In adults increased internal adiposity is associated with elevated intrahepatocellular lipid (IHCL). We measured IHCL using 1H NMR spectroscopy in 26 infants (eight healthy preterm-at-term and 18 term-born) and compared values with a reference group of 32 adults. There was no significant difference between adult and term-born IHCL content. In preterm-at-term infants IHCL was significantly elevated when compared with term-born infants and with adults (IHCL CH2/water median (interquartile range): preterm 1.69 (1.04-3.53), term 0.21 (0-0.54) and adult 0.55 (0.08-1.57).

AB - There is increasing evidence that preterm birth is a risk factor for the development of adiposity associated disease, although the pathophysiological basis is unclear. We have previously shown that preterm infants have increased internal abdominal (visceral) adiposity by term. In adults increased internal adiposity is associated with elevated intrahepatocellular lipid (IHCL). We measured IHCL using 1H NMR spectroscopy in 26 infants (eight healthy preterm-at-term and 18 term-born) and compared values with a reference group of 32 adults. There was no significant difference between adult and term-born IHCL content. In preterm-at-term infants IHCL was significantly elevated when compared with term-born infants and with adults (IHCL CH2/water median (interquartile range): preterm 1.69 (1.04-3.53), term 0.21 (0-0.54) and adult 0.55 (0.08-1.57).

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M3 - Article

C2 - 18723779

AN - SCOPUS:51449103396

SN - 1359-2998

VL - 93

SP - f382-f383

JO - Archives of Disease in Childhood: Fetal and Neonatal Edition

JF - Archives of Disease in Childhood: Fetal and Neonatal Edition

IS - 5

ER -

Neonatal intrahepatocellular lipid

Abstract

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