Norovirus diarrhea is significantly associated with higher counts of fecal histo-blood group antigen expressing Enterobacter cloacae among black South African infants

Cliff A. Magwira*, Duncan Steele, M. L. Seheri

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

1 Citation (Scopus)

Abstract

The study tested the hypothesis that harboring high levels of histo-blood group antigen-expressing Enerobactero cloacae is a risk factor for norovirus diarrhea. The fecal E. cloacae abundance in diarrheic norovirus positive (DNP), non-diarrheic norovirus negative (NDNN), diarrhea norovirus negative (DNN), and non-diarrhea norovirus positive (NDNP) infants was determined by qPCR, and the risk of norovirus diarrhea was assessed by logistical regression. DNP infants contained significantly higher counts of E. cloacae than NDNN and DNN infants, p = .0294, and 0.0001, respectively. The risk of norovirus diarrhea was significantly high in infants with higher counts of E. cloacae than those with lower counts, p = .009. Harboring higher counts of E. cloacae is a risk factor for norovirus diarrhea.

Original languageEnglish
Article number1979876
JournalGut Microbes
Volume13
Issue number1
DOIs
Publication statusPublished - 2021

Keywords

  • Diarrhea
  • E. cloacae
  • abundance
  • histo-blood group antigens
  • norovirus infection

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