TY - JOUR
T1 - Nutritional status influences plasma fibrinogen concentration evidence from the THUSA survey
AU - James, Santhamma
AU - Vorster, Hester H.
AU - Venter, Christina S.
AU - Kruger, H. Salomé
AU - Nell, Theo A.
AU - Veldman, Frederick Johannes
AU - Ubbink, Johan B.
N1 - Funding Information:
This study was funded by the National Research Foundation, the SA Medical Research Council, the SA Dry Bean Producers Organisation, and the SA Sugar Association. Our sincere thanks to all the postgraduate students and fieldworkers. It was a joy to work with such an enthusiastic team. Our gratitude goes to all the participants. It was both a learning and an enriching experience to work among you. It was humbling to see how well people coped in very adverse circumstances.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2000/6/1
Y1 - 2000/6/1
N2 - Nutritional status and risk factors for chronic diseases, including plasma fibrinogen and its determinants, of Africans in the Northwest Province of South Africa, have been studied in a cross-sectional survey. A representative sample of 1854 'apparently healthy' African men and women volunteers aged 15 years and older was recruited from 37 randomly selected sites throughout the Province and stratified for level of urbanisation. Information was collected using validated and culture-sensitive questionnaires. Fasting blood samples were drawn, and all measurements were done with standardised methodology using appropriate equipment, procedures, and controls. Fibrinogen concentration was measured in citrated plasma with the method of Clauss, using the ACL200 automated system and the international fibrinogen standard. The results revealed a population with a high mean plasma fibrinogen (3.17±1.10 g/L for HIV-negative men and 3.64±1.12 g/L for HIV-negative women). Factors known to influence plasma fibrinogen, such as age, gender, smoking habit, and physical activity, were also observed in this population. Young rural men and women had the lowest fibrinogen level. Nasal snuff taking and HIV infection did not influence fibrinogen concentration. Multivariate analyses revealed that lower plasma fibrinogen was associated with low to normal body mass index in women, and with dietary intakes compatible with prudent dietary guidelines in men and women (low intakes of animal protein; trans fatty acids and higher intakes of plant protein; dietary fibre, vitamin E, and iron, and a high dietary P/S ratio). Subjects in the higher quartiles of plasma fibrinogen had significantly lower iron, vitamin E, and vitamin B6 (women) status. Increases in fibrinogen were associated with significant increases in serum lipids. Both under- and overnutrition seem to be associated with high plasma fibrinogen. It is concluded that overall nutritional status, possibly in addition to specific nutrients (and foods), influences plasma fibrinogen. Copyright (C) 2000 Elsevier Science Ltd.
AB - Nutritional status and risk factors for chronic diseases, including plasma fibrinogen and its determinants, of Africans in the Northwest Province of South Africa, have been studied in a cross-sectional survey. A representative sample of 1854 'apparently healthy' African men and women volunteers aged 15 years and older was recruited from 37 randomly selected sites throughout the Province and stratified for level of urbanisation. Information was collected using validated and culture-sensitive questionnaires. Fasting blood samples were drawn, and all measurements were done with standardised methodology using appropriate equipment, procedures, and controls. Fibrinogen concentration was measured in citrated plasma with the method of Clauss, using the ACL200 automated system and the international fibrinogen standard. The results revealed a population with a high mean plasma fibrinogen (3.17±1.10 g/L for HIV-negative men and 3.64±1.12 g/L for HIV-negative women). Factors known to influence plasma fibrinogen, such as age, gender, smoking habit, and physical activity, were also observed in this population. Young rural men and women had the lowest fibrinogen level. Nasal snuff taking and HIV infection did not influence fibrinogen concentration. Multivariate analyses revealed that lower plasma fibrinogen was associated with low to normal body mass index in women, and with dietary intakes compatible with prudent dietary guidelines in men and women (low intakes of animal protein; trans fatty acids and higher intakes of plant protein; dietary fibre, vitamin E, and iron, and a high dietary P/S ratio). Subjects in the higher quartiles of plasma fibrinogen had significantly lower iron, vitamin E, and vitamin B6 (women) status. Increases in fibrinogen were associated with significant increases in serum lipids. Both under- and overnutrition seem to be associated with high plasma fibrinogen. It is concluded that overall nutritional status, possibly in addition to specific nutrients (and foods), influences plasma fibrinogen. Copyright (C) 2000 Elsevier Science Ltd.
KW - Africans
KW - Cardiovascular disease risk factors
KW - Dietary fibre
KW - Fibrinogen
KW - HIV
KW - Nutritional status
KW - THUSA
KW - Trans fatty acids
UR - http://www.scopus.com/inward/record.url?scp=0034212294&partnerID=8YFLogxK
U2 - 10.1016/S0049-3848(00)00197-3
DO - 10.1016/S0049-3848(00)00197-3
M3 - Article
C2 - 10828478
SN - 0049-3848
VL - 98
SP - 383
EP - 394
JO - Thrombosis Research
JF - Thrombosis Research
IS - 5
ER -