Oral mucosal immunity

L. Feller*, M. Altini, R. A.G. Khammissa, R. Chandran, M. Bouckaert, J. Lemmer

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

39 Citations (Scopus)

Abstract

Oral keratinocytes and dendritic cells of the oral mucosa, through molecular pattern recognition receptors, distinguish between commensal and pathogenic microorganisms and mediate the generation of protective immunoinflammatory responses to potentially invading pathogens or mediate immune tolerance toward commensal microorganisms. Oral immune tolerance is the result either of lack of activation of T cells in response to immunogenic presentation of antigens or of suppression of activity of effector T cells by regulatory T cells. Secretory immunoglobulin A (sIgA) antibodies at oral mucosal sites contribute to oral immunity by limiting colonization of microorganisms and their invasion of the epithelium. Ig isotype class switching to IgA is either dependent on or independent of T helper cells and is facilitated by cytokines secreted by dendritic cells and monocytes.

Original languageEnglish
Pages (from-to)576-583
Number of pages8
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume116
Issue number5
DOIs
Publication statusPublished - Nov 2013
Externally publishedYes

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