Oral ulcers and necrotizing gingivitis in relation to HIV-associated neutropenia: A review and an illustrative case

Liviu Feller*, Razia A.G. Khammissa, Neil H. Wood, Robin Meyerov, Liron Pantanowitz, Johan Lemmer

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)

Abstract

An unusual case of necrotizing gingivitis and neutropenic oral ulcers in an HIV-seropositive patient is presented. In spite of a very low CD4 + T cell count and severe neutropenia, the necrotizing gingivitis responded favorably to standard periodontal treatment, and the oral ulcers healed after administration of granulocyte colony-stimulating factor (G-CSF). Nonspecific oral ulcers in HIV-seropositive subjects with neutropenia should be regarded as neutropenic ulcers. The term nonspecific ulcers should be restricted to those ulcers with nonspecific histopathological features in patients without neutropenia or a nutritional deficiency such as iron, folic acid, and vitamin B.

Original languageEnglish
Pages (from-to)346-351
Number of pages6
JournalAIDS Research and Human Retroviruses
Volume28
Issue number4
DOIs
Publication statusPublished - 1 Apr 2012
Externally publishedYes

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