TY - JOUR
T1 - Oral ulcers and necrotizing gingivitis in relation to HIV-associated neutropenia
T2 - A review and an illustrative case
AU - Feller, Liviu
AU - Khammissa, Razia A.G.
AU - Wood, Neil H.
AU - Meyerov, Robin
AU - Pantanowitz, Liron
AU - Lemmer, Johan
PY - 2012/4/1
Y1 - 2012/4/1
N2 - An unusual case of necrotizing gingivitis and neutropenic oral ulcers in an HIV-seropositive patient is presented. In spite of a very low CD4 + T cell count and severe neutropenia, the necrotizing gingivitis responded favorably to standard periodontal treatment, and the oral ulcers healed after administration of granulocyte colony-stimulating factor (G-CSF). Nonspecific oral ulcers in HIV-seropositive subjects with neutropenia should be regarded as neutropenic ulcers. The term nonspecific ulcers should be restricted to those ulcers with nonspecific histopathological features in patients without neutropenia or a nutritional deficiency such as iron, folic acid, and vitamin B.
AB - An unusual case of necrotizing gingivitis and neutropenic oral ulcers in an HIV-seropositive patient is presented. In spite of a very low CD4 + T cell count and severe neutropenia, the necrotizing gingivitis responded favorably to standard periodontal treatment, and the oral ulcers healed after administration of granulocyte colony-stimulating factor (G-CSF). Nonspecific oral ulcers in HIV-seropositive subjects with neutropenia should be regarded as neutropenic ulcers. The term nonspecific ulcers should be restricted to those ulcers with nonspecific histopathological features in patients without neutropenia or a nutritional deficiency such as iron, folic acid, and vitamin B.
UR - http://www.scopus.com/inward/record.url?scp=84859187669&partnerID=8YFLogxK
U2 - 10.1089/aid.2011.0141
DO - 10.1089/aid.2011.0141
M3 - Review article
C2 - 21728927
AN - SCOPUS:84859187669
SN - 0889-2229
VL - 28
SP - 346
EP - 351
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
IS - 4
ER -
