TY - JOUR
T1 - Orally disintegrating drug carriers for paediatric pharmacotherapy
AU - Kean, Emma A.
AU - Adeleke, Oluwatoyin A.
N1 - Funding Information:
This work was supported through Research Establishment Grants awarded by the Faculty of Health and College of Pharmacy, Dalhousie University (Grant ID: R34000 ). The content is solely the responsibility of the authors and does not necessarily represent the official views of the funders.
Publisher Copyright:
© 2023 The Author(s)
PY - 2023/3/1
Y1 - 2023/3/1
N2 - Non-compliance, dosing inaccuracy, choking risk, flavour, and instability, are some of the issues associated with paediatric, oral dosage forms — tablets, capsules, solutions, and suspensions. Orally disintegrating drug carriers, a dosage form with growing interest, are thought to overcome several of the challenges associated with these conventional formulations by rapidly disintegrating within the buccal cavity without the need for water. This review serves as an up-to-date report on the various types of orodispersible delivery systems, currently being developed or commercialized, by detailing their characteristics, manufacturing processes, and applications in the paediatric population. Mentioned are orodispersible tablets, films, wafers and lyophilisates, mini-tablets, capsules, granules, electrospun fibers and webs. Also highlighted are the choice of excipients, quality control requirements, and expected pharmacokinetics of orally disintegrating drug carriers concerning the paediatric population. Overall, orodispersible formulations, particularly tablets, films, and lyophilisates/wafers, have shown to be a valuable addition to medication administration in minors, thus the execution of more targeted research and development activities is expected to lead to enhanced paediatric care and outcomes.
AB - Non-compliance, dosing inaccuracy, choking risk, flavour, and instability, are some of the issues associated with paediatric, oral dosage forms — tablets, capsules, solutions, and suspensions. Orally disintegrating drug carriers, a dosage form with growing interest, are thought to overcome several of the challenges associated with these conventional formulations by rapidly disintegrating within the buccal cavity without the need for water. This review serves as an up-to-date report on the various types of orodispersible delivery systems, currently being developed or commercialized, by detailing their characteristics, manufacturing processes, and applications in the paediatric population. Mentioned are orodispersible tablets, films, wafers and lyophilisates, mini-tablets, capsules, granules, electrospun fibers and webs. Also highlighted are the choice of excipients, quality control requirements, and expected pharmacokinetics of orally disintegrating drug carriers concerning the paediatric population. Overall, orodispersible formulations, particularly tablets, films, and lyophilisates/wafers, have shown to be a valuable addition to medication administration in minors, thus the execution of more targeted research and development activities is expected to lead to enhanced paediatric care and outcomes.
KW - Child-appropriate dosage forms
KW - Excipients
KW - Manufacturing processes
KW - Orally disintegrating drug carriers
KW - Orodispersible drug delivery systems
KW - Orodispersible drug formulations
KW - Paediatric medicines
UR - http://www.scopus.com/inward/record.url?scp=85146159738&partnerID=8YFLogxK
U2 - 10.1016/j.ejps.2023.106377
DO - 10.1016/j.ejps.2023.106377
M3 - Review article
C2 - 36634740
AN - SCOPUS:85146159738
SN - 0928-0987
VL - 182
JO - European Journal of Pharmaceutical Sciences
JF - European Journal of Pharmaceutical Sciences
M1 - 106377
ER -