Current treatment of tuberculosis is inadequate due to lengthy treatment course and drug-related toxicity. To address these setbacks, we developed a nanotechnology drug delivery system that can be administered in a single dose that maintains an active level of drug for at least a week. Polymeric poly(lactic-co-glycolic acid) nanoparticles of 200-300 nm were synthesized, with a drug encapsulation efficiency of 50-65% for isoniazid and rifampicin. The particles were taken up in vitro and in vivo and a slow release profile was observed in mice over 5 days. This study illustrates the feasibility of a sustained release system for tuberculosis treatment. © Taylor & Francis Group, LLC.
|Number of pages||14|
|Publication status||Published - 1 Jun 2012|
|Event||Molecular Crystals and Liquid Crystals - |
Duration: 1 Jun 2012 → …
|Conference||Molecular Crystals and Liquid Crystals|
|Period||01/Jun/12 → …|