TY - JOUR
T1 - Premium ethylcellulose polymer based architectures at work in drug delivery
AU - Adeleke, Oluwatoyin Ayotomilola
N1 - Funding Information:
OA acknowledges the Division of Intramural Research Program, National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Health (NIH) for grant support and the U.S.-South Africa Program for Collaborative Biomedical Research for fellowship through grant number U01AI115940. OA also appreciates the South African National Research Foundation for research funding provided through grant number 113143. The University of Cape Town and Sefako Makgatho Health Sciences University (SMU), South Africa are also acknowledged for provision of supplementary funds. Thanks to Neo Tilodi, Waseem Hassim, Njabulo Hlatwayo and Bridgette Maruma from the School of Pharmacy at SMU for preliminary data collection. OA specially recognizes Dr. Alan Sher from the Laboratory for Parasitic Diseases, NIAID, NIH for his valuable advice and conversations. The views expressed in this manuscript are those of the author and do not necessarily reflect the position of the funders.
Funding Information:
OA acknowledges the Division of Intramural Research Program , National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Health (NIH) for grant support and the U.S.-South Africa Program for Collaborative Biomedical Research for fellowship through grant number U01AI115940. OA also appreciates the South African National Research Foundation for research funding provided through grant number 113143. The University of Cape Town and Sefako Makgatho Health Sciences University (SMU), South Africa are also acknowledged for provision of supplementary funds. Thanks to Neo Tilodi, Waseem Hassim, Njabulo Hlatwayo and Bridgette Maruma from the School of Pharmacy at SMU for preliminary data collection. OA specially recognizes Dr. Alan Sher from the Laboratory for Parasitic Diseases, NIAID, NIH for his valuable advice and conversations. The views expressed in this manuscript are those of the author and do not necessarily reflect the position of the funders.
Publisher Copyright:
© 2019
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - © 2019 Premium ethylcellulose polymers are hydrophobic cellulose ether based biomaterials widely employed as biocompatible templates for the design of novel drug delivery systems. They are classified as United States Food and Drug Administration Generally-Recognized-As-Safe chemical substances and have been extensively utilized within the biomedical and pharmaceutical industries for over half a century. They have so far demonstrated the potential to modulate and improve the physiological performance of bioactives leading to the desired enhanced prophylactic and therapeutic outcomes. This review therefore presents a scholarly survey of inter-disciplinary developments focused on the functionalities of ethylcellulose polymers as biomaterials useful for the design of smart delivery architectures for relevant pharmacotherapeutic biomedical applications. Emphasis was placed on evaluating scientific resources related to recent advancements and future directions associated with its applications as delivery systems for drugs and biologics within the past decade thus complementing other specialized reviews showcasing the theme.
AB - © 2019 Premium ethylcellulose polymers are hydrophobic cellulose ether based biomaterials widely employed as biocompatible templates for the design of novel drug delivery systems. They are classified as United States Food and Drug Administration Generally-Recognized-As-Safe chemical substances and have been extensively utilized within the biomedical and pharmaceutical industries for over half a century. They have so far demonstrated the potential to modulate and improve the physiological performance of bioactives leading to the desired enhanced prophylactic and therapeutic outcomes. This review therefore presents a scholarly survey of inter-disciplinary developments focused on the functionalities of ethylcellulose polymers as biomaterials useful for the design of smart delivery architectures for relevant pharmacotherapeutic biomedical applications. Emphasis was placed on evaluating scientific resources related to recent advancements and future directions associated with its applications as delivery systems for drugs and biologics within the past decade thus complementing other specialized reviews showcasing the theme.
KW - Cellulose derivative
KW - Hydrophobic biomaterial
KW - Pharmaceutical excipient
KW - Polymeric biomaterial
KW - Polymeric drug delivery
UR - http://www.scopus.com/inward/record.url?scp=85070061567&partnerID=8YFLogxK
U2 - 10.1016/j.ijpx.2019.100023
DO - 10.1016/j.ijpx.2019.100023
M3 - Article
SN - 2590-1567
VL - 1
JO - International Journal of Pharmaceutics: X
JF - International Journal of Pharmaceutics: X
M1 - 100023
ER -