Recent Advances in the Therapeutic Efficacy of Artesunate

Ngonidzashe Ruwizhi; Rejoice Bethusile Maseko; Blessing Atim Aderibigbe

doi:10.3390/pharmaceutics14030504

Recent Advances in the Therapeutic Efficacy of Artesunate

Ngonidzashe Ruwizhi, Rejoice Bethusile Maseko^*, Blessing Atim Aderibigbe^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Review article › peer-review

28 Citations (Scopus)

Abstract

Artesunate, a semisynthetic artemisinin derivative, is well-known and used as the first-line drug for treating malaria. Apart from treating malaria, artesunate has also been found to have biological activity against a variety of cancers and viruses. It also exhibits antidiabetic, anti-inflammatory, anti-atherosclerosis, immunosuppressive activities, etc. During its administration, artesunate can be loaded in liposomes, alone or in combination with other therapeutic agents. Administration routes include intragastrical, intravenous, oral, and parenteral. The biological activity of artesunate is based on its ability to regulate some biological pathways. This manuscript reports a critical review of the recent advances in the therapeutic efficacy of artesunate.

Original language	English
Article number	504
Journal	Pharmaceutics
Volume	14
Issue number	3
DOIs	https://doi.org/10.3390/pharmaceutics14030504
Publication status	Published - Mar 2022

Keywords

Anticancer
Antiviral
Artesunate
COVID-19
Malaria
Skin diseases
Tumour

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/pharmaceutics14030504

Cite this

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title = "Recent Advances in the Therapeutic Efficacy of Artesunate",

abstract = "Artesunate, a semisynthetic artemisinin derivative, is well-known and used as the first-line drug for treating malaria. Apart from treating malaria, artesunate has also been found to have biological activity against a variety of cancers and viruses. It also exhibits antidiabetic, anti-inflammatory, anti-atherosclerosis, immunosuppressive activities, etc. During its administration, artesunate can be loaded in liposomes, alone or in combination with other therapeutic agents. Administration routes include intragastrical, intravenous, oral, and parenteral. The biological activity of artesunate is based on its ability to regulate some biological pathways. This manuscript reports a critical review of the recent advances in the therapeutic efficacy of artesunate.",

keywords = "Anticancer, Antiviral, Artesunate, COVID-19, Malaria, Skin diseases, Tumour",

author = "Ngonidzashe Ruwizhi and Maseko, {Rejoice Bethusile} and Aderibigbe, {Blessing Atim}",

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doi = "10.3390/pharmaceutics14030504",

language = "English",

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AU - Ruwizhi, Ngonidzashe

AU - Maseko, Rejoice Bethusile

AU - Aderibigbe, Blessing Atim

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N2 - Artesunate, a semisynthetic artemisinin derivative, is well-known and used as the first-line drug for treating malaria. Apart from treating malaria, artesunate has also been found to have biological activity against a variety of cancers and viruses. It also exhibits antidiabetic, anti-inflammatory, anti-atherosclerosis, immunosuppressive activities, etc. During its administration, artesunate can be loaded in liposomes, alone or in combination with other therapeutic agents. Administration routes include intragastrical, intravenous, oral, and parenteral. The biological activity of artesunate is based on its ability to regulate some biological pathways. This manuscript reports a critical review of the recent advances in the therapeutic efficacy of artesunate.

AB - Artesunate, a semisynthetic artemisinin derivative, is well-known and used as the first-line drug for treating malaria. Apart from treating malaria, artesunate has also been found to have biological activity against a variety of cancers and viruses. It also exhibits antidiabetic, anti-inflammatory, anti-atherosclerosis, immunosuppressive activities, etc. During its administration, artesunate can be loaded in liposomes, alone or in combination with other therapeutic agents. Administration routes include intragastrical, intravenous, oral, and parenteral. The biological activity of artesunate is based on its ability to regulate some biological pathways. This manuscript reports a critical review of the recent advances in the therapeutic efficacy of artesunate.

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KW - Artesunate

KW - COVID-19

KW - Malaria

KW - Skin diseases

KW - Tumour

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DO - 10.3390/pharmaceutics14030504

M3 - Review article

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VL - 14

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Recent Advances in the Therapeutic Efficacy of Artesunate

Abstract

Keywords

UN SDGs

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