Relevance of commercial diagnostic tests to detection of enteric adenovirus infections in South Africa

P. L. Moore*, A. D. Steele, J. J. Alexander

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

The prevalence of enteric adenoviruses detected by an in-house enzyme- linked immunosorbent assay (the RIVM-ELISA) ranged from 13 to 38%, and subgroup F adenoviruses comprised 86%. All subgroup F adenoviruses reacted with both RIVM anti-adenovirus type 40 (Ad40) and anti-adenovirus type 41 (Ad41) monoclonal antibodies but were not detected by Adenoclone Type 40/41 enzyme immunoassay (EIA). The correlation between the Biotrin EIA and RIVM- ELISA results was low (26%). Immunospecific tests suggest that a significant proportion of enteric adenoviruses, possibly comprising previously unidentified or emerging types, are not detected by commercial diagnostic tests in South Africa.

Original languageEnglish
Pages (from-to)1661-1663
Number of pages3
JournalJournal of Clinical Microbiology
Volume38
Issue number4
DOIs
Publication statusPublished - 2000

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