Role of astrovirus in intussusception in Nigerian infants

M. Aminu; E. A. Ameh; A. Geyer; M. D. Esona; M. B. Taylor; A. D. Steele

doi:10.1093/tropej/fmn101

Role of astrovirus in intussusception in Nigerian infants

M. Aminu^*, E. A. Ameh, A. Geyer, M. D. Esona, M. B. Taylor, A. D. Steele

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Intussusception (IS) is a form of intestinal obstruction in which a segment of the bowel prolapses into a more distal segment. Viral infections, mostly adenovirus, enteroviruses, human herpesvirus and Epstein-Barr virus are reported in 20-50% of childhood cases of IS. Between January and July 2004, six stool specimens collected from infants 0- to 8-months old diagnosed and admitted for IS were investigated for the presence of rotavirus, astrovirus and adenovirus antigens. Astrovirus antigen was detected in three of the six stool specimens by enzyme immune assay (EIA) and confirmed in two specimens by reverse transcription-polymerase chain reaction (RT-PCR). Rotavirus, non-enteric adenovirus and astrovirus were detected by EIA, as mixed infections in a single specimen. The rotavirus strain revealed a SGI+II, mixed G1G2G8P[6] genotype and had no visible electrophoretic profile. A larger study is needed to determine the extent of involvement of astroviruses in IS in infants and the virus should be included in studies investigating the aetiology of IS.

Original language	English
Pages (from-to)	192-194
Number of pages	3
Journal	Journal of Tropical Pediatrics
Volume	55
Issue number	3
DOIs	https://doi.org/10.1093/tropej/fmn101
Publication status	Published - 2009
Externally published	Yes

Keywords

Astroviruses
Infants
Intussusception

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Role of astrovirus in intussusception in Nigerian infants",

abstract = "Intussusception (IS) is a form of intestinal obstruction in which a segment of the bowel prolapses into a more distal segment. Viral infections, mostly adenovirus, enteroviruses, human herpesvirus and Epstein-Barr virus are reported in 20-50% of childhood cases of IS. Between January and July 2004, six stool specimens collected from infants 0- to 8-months old diagnosed and admitted for IS were investigated for the presence of rotavirus, astrovirus and adenovirus antigens. Astrovirus antigen was detected in three of the six stool specimens by enzyme immune assay (EIA) and confirmed in two specimens by reverse transcription-polymerase chain reaction (RT-PCR). Rotavirus, non-enteric adenovirus and astrovirus were detected by EIA, as mixed infections in a single specimen. The rotavirus strain revealed a SGI+II, mixed G1G2G8P[6] genotype and had no visible electrophoretic profile. A larger study is needed to determine the extent of involvement of astroviruses in IS in infants and the virus should be included in studies investigating the aetiology of IS.",

keywords = "Astroviruses, Infants, Intussusception",

author = "M. Aminu and Ameh, {E. A.} and A. Geyer and Esona, {M. D.} and Taylor, {M. B.} and Steele, {A. D.}",

note = "Funding Information: This study is part of a larger study sponsored by UNESCO-L{\textquoteright}OR{\'E}AL Fellowship for Women in Life Sciences for one of the authors, Aminu Maryam.",

year = "2009",

doi = "10.1093/tropej/fmn101",

language = "English",

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AU - Ameh, E. A.

AU - Geyer, A.

AU - Esona, M. D.

AU - Taylor, M. B.

AU - Steele, A. D.

N1 - Funding Information: This study is part of a larger study sponsored by UNESCO-L’ORÉAL Fellowship for Women in Life Sciences for one of the authors, Aminu Maryam.

PY - 2009

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N2 - Intussusception (IS) is a form of intestinal obstruction in which a segment of the bowel prolapses into a more distal segment. Viral infections, mostly adenovirus, enteroviruses, human herpesvirus and Epstein-Barr virus are reported in 20-50% of childhood cases of IS. Between January and July 2004, six stool specimens collected from infants 0- to 8-months old diagnosed and admitted for IS were investigated for the presence of rotavirus, astrovirus and adenovirus antigens. Astrovirus antigen was detected in three of the six stool specimens by enzyme immune assay (EIA) and confirmed in two specimens by reverse transcription-polymerase chain reaction (RT-PCR). Rotavirus, non-enteric adenovirus and astrovirus were detected by EIA, as mixed infections in a single specimen. The rotavirus strain revealed a SGI+II, mixed G1G2G8P[6] genotype and had no visible electrophoretic profile. A larger study is needed to determine the extent of involvement of astroviruses in IS in infants and the virus should be included in studies investigating the aetiology of IS.

AB - Intussusception (IS) is a form of intestinal obstruction in which a segment of the bowel prolapses into a more distal segment. Viral infections, mostly adenovirus, enteroviruses, human herpesvirus and Epstein-Barr virus are reported in 20-50% of childhood cases of IS. Between January and July 2004, six stool specimens collected from infants 0- to 8-months old diagnosed and admitted for IS were investigated for the presence of rotavirus, astrovirus and adenovirus antigens. Astrovirus antigen was detected in three of the six stool specimens by enzyme immune assay (EIA) and confirmed in two specimens by reverse transcription-polymerase chain reaction (RT-PCR). Rotavirus, non-enteric adenovirus and astrovirus were detected by EIA, as mixed infections in a single specimen. The rotavirus strain revealed a SGI+II, mixed G1G2G8P[6] genotype and had no visible electrophoretic profile. A larger study is needed to determine the extent of involvement of astroviruses in IS in infants and the virus should be included in studies investigating the aetiology of IS.

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DO - 10.1093/tropej/fmn101

M3 - Article

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AN - SCOPUS:67049161217

SN - 0142-6338

VL - 55

SP - 192

EP - 194

JO - Journal of Tropical Pediatrics

JF - Journal of Tropical Pediatrics

IS - 3

ER -

Role of astrovirus in intussusception in Nigerian infants

Abstract

Keywords

UN SDGs

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