Rotavirus vaccines: Update on global impact and future priorities

Catherine Yen*, Jacqueline E. Tate, Manish M. Patel, Margaret M. Cortese, Benjamin Lopman, Jessica Fleming, Kristen Lewis, Baoming Jiang, Jon Gentsch, Duncan Steele, Umesh D. Parashar

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

54 Citations (Scopus)

Abstract

Early rotavirus vaccine adopter countries in the Americas, Europe, and in Australia have documented substantial declines in rotavirus disease burden following the introduction of vaccination. However, the full public health impact of rotavirus vaccines has not been realized as they have not been introduced into routine immunization programs in countries of Africa and Asia with the highest rotavirus disease morbidity and mortality burden. In this article, we review the epidemiology of rotavirus disease, the development and current status of rotavirus vaccines including newly available vaccine impact data from early-introducer countries, and future priorities for implementation and monitoring of rotavirus vaccination programs in developing countries.

Original languageEnglish
Pages (from-to)1282-1290
Number of pages9
JournalHuman Vaccines
Volume7
Issue number12
DOIs
Publication statusPublished - Dec 2011
Externally publishedYes

Keywords

  • Gastroenteritis
  • Rotavirus
  • Rotavirus vaccines
  • Vaccine impact
  • Vaccines

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