TY - JOUR
T1 - Rotavirus VP4 and VP7 genotypes circulating in cameroon
T2 - Identification of unusual types
AU - Esona, Matthew D.
AU - Armah, George E.
AU - Steele, A. Duncan
N1 - Funding Information:
Supplement sponsorship: This article is part of a supplement entitled “Rotavirus Infection In Africa: Epidemiology, Burden of Disease, and Strain Diversity,” which was prepared as a project of the Rotavirus Vaccine Program, a partnership among PATH, the World Health Organization, and the US Centers for Disease Control and Prevention, and was funded in full or in part by the GAVI Alliance.
Funding Information:
Financial support: World Health Organization (grant V27/181/113), South African Medical Research Council, Norwegian Programme for Development, Research and Higher Education (research grant PRO 48/2002), Rotavirus Vaccine Program, PATH (grant GAV.1142–01-07211-SPS), and Research Council of Norway (grant 146184/ 730, postdoctoral fellowship to M.D.E.).
PY - 2010/9/1
Y1 - 2010/9/1
N2 - Rotavirus remains a priority candidate for vaccine development, because it is the major cause of viral diarrhea in children worldwide. This study characterized rotavirus strains in 195 stool specimens collected fromchildren <5 years of age with diarrhea, in the Southwest Province and Western Province of Cameroon during 1999- 2000. The predominant G type was G1 (detected in 44.9% of specimens) and the most predominant P type was P[8] (in 82.7%). The most common G-P combination detected was G1P[8] (in 37.1% of specimens), followed by G9P[8] (in 14%). Rotavirus strains with unusual G-P combinations, such as G1P[4], G2P[8], G8P[8], G9P[4], G5P[8], and G10P[8], were also observed in significant numbers. Analysis of the age distribution showed that G1P[8] was found circulating in all age groups except in infants <6 months old. Strains G2P[4] and G3P[8] were identified in children >37 months and 19-24 months of age, respectively. Strain G9P[8] was found circulating among children >25 months of age. Unusual strains and mixed infections were found circulating in the different age groups, albeit at lower levels. The high prevalence of mixed infections and diversity of rotavirus strains detected in this first study based on genotyping of Cameroonian strains reinforce the need to continue with surveillance programs in Africa, where a high diversity of strains has beenreported.
AB - Rotavirus remains a priority candidate for vaccine development, because it is the major cause of viral diarrhea in children worldwide. This study characterized rotavirus strains in 195 stool specimens collected fromchildren <5 years of age with diarrhea, in the Southwest Province and Western Province of Cameroon during 1999- 2000. The predominant G type was G1 (detected in 44.9% of specimens) and the most predominant P type was P[8] (in 82.7%). The most common G-P combination detected was G1P[8] (in 37.1% of specimens), followed by G9P[8] (in 14%). Rotavirus strains with unusual G-P combinations, such as G1P[4], G2P[8], G8P[8], G9P[4], G5P[8], and G10P[8], were also observed in significant numbers. Analysis of the age distribution showed that G1P[8] was found circulating in all age groups except in infants <6 months old. Strains G2P[4] and G3P[8] were identified in children >37 months and 19-24 months of age, respectively. Strain G9P[8] was found circulating among children >25 months of age. Unusual strains and mixed infections were found circulating in the different age groups, albeit at lower levels. The high prevalence of mixed infections and diversity of rotavirus strains detected in this first study based on genotyping of Cameroonian strains reinforce the need to continue with surveillance programs in Africa, where a high diversity of strains has beenreported.
UR - http://www.scopus.com/inward/record.url?scp=77955665969&partnerID=8YFLogxK
U2 - 10.1086/653575
DO - 10.1086/653575
M3 - Article
C2 - 20684704
AN - SCOPUS:77955665969
SN - 0022-1899
VL - 202
SP - S205-S211
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - SUPPL. 1
ER -
