Screening on receptor tyrosine kinase inhibitory activity of marine algae-derived symbiotic microorganisms

Keumja Yun; Guohua Yang; Zhile Feng; Viviane N. Nenkep; Xavier; Alain S. Leutou; Gun Do Kim; Heeyeong Cho; Hong Dae Choi; Byeng Wha Son

Screening on receptor tyrosine kinase inhibitory activity of marine algae-derived symbiotic microorganisms

Keumja Yun^*, Guohua Yang, Zhile Feng, Viviane N. Nenkep, Xavier, Siwe-Noundou, Alain S. Leutou, Gun Do Kim, Heeyeong Cho, Hong Dae Choi, Byeng Wha Son

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

In order to screen new receptor tyrosine kinase inhibitor which is expected to be anticancer drug lead, we have investigated receptor tyrosine kinase inhibitory activity on the marine alga-derived symbiotic microorganisms (500 strains). The significant activities (over 70% inhibition at 10 μg/ml) were observed in the extracts of ten strains (Strain No.: MFA018, 019, 206, 242, 325, 335, 343, 344, 354, 356), isolated from marine red algae, five strains (Strain No.: MFA030, 126, 213, 324, 339), isolated from the brown algae, and one strain (Strain No.: MFA272), isolated from the marine green algae, respectively. Among the active strains, MFA019 and 356 showed strong receptor tyrosine kinase inhibitory activity with IC ₅₀ values of 0.6 and 0.9 μg/ml, respectively.

Original language	English
Pages (from-to)	43-47
Number of pages	5
Journal	Korean Journal of Pharmacognosy
Volume	41
Issue number	1
Publication status	Published - Mar 2010
Externally published	Yes

Keywords

Antitumor drug lead
Marine algae
Receptor tyrosine kinase (RTK) inhibitor
Symbiotic marine microorganism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Screening on receptor tyrosine kinase inhibitory activity of marine algae-derived symbiotic microorganisms",

abstract = "In order to screen new receptor tyrosine kinase inhibitor which is expected to be anticancer drug lead, we have investigated receptor tyrosine kinase inhibitory activity on the marine alga-derived symbiotic microorganisms (500 strains). The significant activities (over 70% inhibition at 10 μg/ml) were observed in the extracts of ten strains (Strain No.: MFA018, 019, 206, 242, 325, 335, 343, 344, 354, 356), isolated from marine red algae, five strains (Strain No.: MFA030, 126, 213, 324, 339), isolated from the brown algae, and one strain (Strain No.: MFA272), isolated from the marine green algae, respectively. Among the active strains, MFA019 and 356 showed strong receptor tyrosine kinase inhibitory activity with IC 50 values of 0.6 and 0.9 μg/ml, respectively.",

keywords = "Antitumor drug lead, Marine algae, Receptor tyrosine kinase (RTK) inhibitor, Symbiotic marine microorganism",

author = "Keumja Yun and Guohua Yang and Zhile Feng and Nenkep, {Viviane N.} and Xavier and Siwe-Noundou and Leutou, {Alain S.} and Kim, {Gun Do} and Heeyeong Cho and Choi, {Hong Dae} and Son, {Byeng Wha}",

year = "2010",

month = mar,

language = "English",

volume = "41",

pages = "43--47",

journal = "Korean Journal of Pharmacognosy",

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publisher = "Korean Society of Pharmacognosy",

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TY - JOUR

T1 - Screening on receptor tyrosine kinase inhibitory activity of marine algae-derived symbiotic microorganisms

AU - Yun, Keumja

AU - Yang, Guohua

AU - Feng, Zhile

AU - Nenkep, Viviane N.

AU - Xavier,

AU - Siwe-Noundou,

AU - Leutou, Alain S.

AU - Kim, Gun Do

AU - Cho, Heeyeong

AU - Choi, Hong Dae

AU - Son, Byeng Wha

PY - 2010/3

Y1 - 2010/3

N2 - In order to screen new receptor tyrosine kinase inhibitor which is expected to be anticancer drug lead, we have investigated receptor tyrosine kinase inhibitory activity on the marine alga-derived symbiotic microorganisms (500 strains). The significant activities (over 70% inhibition at 10 μg/ml) were observed in the extracts of ten strains (Strain No.: MFA018, 019, 206, 242, 325, 335, 343, 344, 354, 356), isolated from marine red algae, five strains (Strain No.: MFA030, 126, 213, 324, 339), isolated from the brown algae, and one strain (Strain No.: MFA272), isolated from the marine green algae, respectively. Among the active strains, MFA019 and 356 showed strong receptor tyrosine kinase inhibitory activity with IC 50 values of 0.6 and 0.9 μg/ml, respectively.

AB - In order to screen new receptor tyrosine kinase inhibitor which is expected to be anticancer drug lead, we have investigated receptor tyrosine kinase inhibitory activity on the marine alga-derived symbiotic microorganisms (500 strains). The significant activities (over 70% inhibition at 10 μg/ml) were observed in the extracts of ten strains (Strain No.: MFA018, 019, 206, 242, 325, 335, 343, 344, 354, 356), isolated from marine red algae, five strains (Strain No.: MFA030, 126, 213, 324, 339), isolated from the brown algae, and one strain (Strain No.: MFA272), isolated from the marine green algae, respectively. Among the active strains, MFA019 and 356 showed strong receptor tyrosine kinase inhibitory activity with IC 50 values of 0.6 and 0.9 μg/ml, respectively.

KW - Antitumor drug lead

KW - Marine algae

KW - Receptor tyrosine kinase (RTK) inhibitor

KW - Symbiotic marine microorganism

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M3 - Article

AN - SCOPUS:77958518494

SN - 0253-3073

VL - 41

SP - 43

EP - 47

JO - Korean Journal of Pharmacognosy

JF - Korean Journal of Pharmacognosy

IS - 1

ER -

Screening on receptor tyrosine kinase inhibitory activity of marine algae-derived symbiotic microorganisms

Abstract

Keywords

UN SDGs

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