In order to screen new receptor tyrosine kinase inhibitor which is expected to be anticancer drug lead, we have investigated receptor tyrosine kinase inhibitory activity on the marine alga-derived symbiotic microorganisms (500 strains). The significant activities (over 70% inhibition at 10 μg/ml) were observed in the extracts of ten strains (Strain No.: MFA018, 019, 206, 242, 325, 335, 343, 344, 354, 356), isolated from marine red algae, five strains (Strain No.: MFA030, 126, 213, 324, 339), isolated from the brown algae, and one strain (Strain No.: MFA272), isolated from the marine green algae, respectively. Among the active strains, MFA019 and 356 showed strong receptor tyrosine kinase inhibitory activity with IC 50 values of 0.6 and 0.9 μg/ml, respectively.
|Number of pages||5|
|Journal||Korean Journal of Pharmacognosy|
|Publication status||Published - Mar 2010|
- Antitumor drug lead
- Marine algae
- Receptor tyrosine kinase (RTK) inhibitor
- Symbiotic marine microorganism