Secretor and salivary ABO blood group antigen status predict rotavirus vaccine take in infants

Abdul Momin Kazi; Margaret M. Cortese; Ying Yu; Benjamin Lopman; Ardythe L. Morrow; Jessica A. Fleming; Monica M. McNeal; A. Duncan Steele; Umesh D. Parashar; Anita K.M. Zaidi; Asad Ali

doi:10.1093/infdis/jix028

Secretor and salivary ABO blood group antigen status predict rotavirus vaccine take in infants

Abdul Momin Kazi, Margaret M. Cortese^*, Ying Yu, Benjamin Lopman, Ardythe L. Morrow, Jessica A. Fleming, Monica M. McNeal, A. Duncan Steele, Umesh D. Parashar, Anita K.M. Zaidi, Asad Ali

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

Histo-blood group antigens (HBGAs) expressed on enterocytes are proposed receptors for rotaviruses and can be measured in saliva. Among 181 Pakistani infants in a G1P[8] rotavirus vaccine trial who were seronegative at baseline, anti-rotavirus immunoglobulin A seroconversion rates after 3 vaccine doses differed significantly by salivary HBGA phenotype, with the lowest rate (19%) among infants who were nonsecretors (ie, who did not express the carbohydrate synthesized by FUT2), an intermediate rate (30%) among secretors with non-blood group O, and the highest rate (51%) among secretors with O blood group. Differences in HBGA expression may be responsible for some of the discrepancy in the level of protection detected for the current rotavirus vaccines in low-income versus high-income settings.

Original language	English
Pages (from-to)	786-789
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	215
Issue number	5
DOIs	https://doi.org/10.1093/infdis/jix028
Publication status	Published - 1 Mar 2017
Externally published	Yes

Keywords

Blood group
FUT2
Infants
Lewis antigen
Rotavirus
Secretor
Vaccine

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10.1093/infdis/jix028

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title = "Secretor and salivary ABO blood group antigen status predict rotavirus vaccine take in infants",

abstract = "Histo-blood group antigens (HBGAs) expressed on enterocytes are proposed receptors for rotaviruses and can be measured in saliva. Among 181 Pakistani infants in a G1P[8] rotavirus vaccine trial who were seronegative at baseline, anti-rotavirus immunoglobulin A seroconversion rates after 3 vaccine doses differed significantly by salivary HBGA phenotype, with the lowest rate (19%) among infants who were nonsecretors (ie, who did not express the carbohydrate synthesized by FUT2), an intermediate rate (30%) among secretors with non-blood group O, and the highest rate (51%) among secretors with O blood group. Differences in HBGA expression may be responsible for some of the discrepancy in the level of protection detected for the current rotavirus vaccines in low-income versus high-income settings.",

keywords = "Blood group, FUT2, Infants, Lewis antigen, Rotavirus, Secretor, Vaccine",

author = "Kazi, {Abdul Momin} and Cortese, {Margaret M.} and Ying Yu and Benjamin Lopman and Morrow, {Ardythe L.} and Fleming, {Jessica A.} and McNeal, {Monica M.} and Steele, {A. Duncan} and Parashar, {Umesh D.} and Zaidi, {Anita K.M.} and Asad Ali",

note = "Funding Information: This work was supported by the Centers for Disease Control and Prevention (contract 200-2015-M-63224) and by PATH (through funding from Gavi).",

year = "2017",

month = mar,

day = "1",

doi = "10.1093/infdis/jix028",

language = "English",

volume = "215",

pages = "786--789",

journal = "Journal of Infectious Diseases",

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AU - Kazi, Abdul Momin

AU - Cortese, Margaret M.

AU - Yu, Ying

AU - Lopman, Benjamin

AU - Morrow, Ardythe L.

AU - Fleming, Jessica A.

AU - McNeal, Monica M.

AU - Steele, A. Duncan

AU - Parashar, Umesh D.

AU - Zaidi, Anita K.M.

AU - Ali, Asad

N1 - Funding Information: This work was supported by the Centers for Disease Control and Prevention (contract 200-2015-M-63224) and by PATH (through funding from Gavi).

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Histo-blood group antigens (HBGAs) expressed on enterocytes are proposed receptors for rotaviruses and can be measured in saliva. Among 181 Pakistani infants in a G1P[8] rotavirus vaccine trial who were seronegative at baseline, anti-rotavirus immunoglobulin A seroconversion rates after 3 vaccine doses differed significantly by salivary HBGA phenotype, with the lowest rate (19%) among infants who were nonsecretors (ie, who did not express the carbohydrate synthesized by FUT2), an intermediate rate (30%) among secretors with non-blood group O, and the highest rate (51%) among secretors with O blood group. Differences in HBGA expression may be responsible for some of the discrepancy in the level of protection detected for the current rotavirus vaccines in low-income versus high-income settings.

AB - Histo-blood group antigens (HBGAs) expressed on enterocytes are proposed receptors for rotaviruses and can be measured in saliva. Among 181 Pakistani infants in a G1P[8] rotavirus vaccine trial who were seronegative at baseline, anti-rotavirus immunoglobulin A seroconversion rates after 3 vaccine doses differed significantly by salivary HBGA phenotype, with the lowest rate (19%) among infants who were nonsecretors (ie, who did not express the carbohydrate synthesized by FUT2), an intermediate rate (30%) among secretors with non-blood group O, and the highest rate (51%) among secretors with O blood group. Differences in HBGA expression may be responsible for some of the discrepancy in the level of protection detected for the current rotavirus vaccines in low-income versus high-income settings.

KW - Blood group

KW - FUT2

KW - Infants

KW - Lewis antigen

KW - Rotavirus

KW - Secretor

KW - Vaccine

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DO - 10.1093/infdis/jix028

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AN - SCOPUS:85019824340

SN - 0022-1899

VL - 215

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EP - 789

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 5

ER -

Secretor and salivary ABO blood group antigen status predict rotavirus vaccine take in infants

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Keywords

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