Secretor and salivary ABO blood group antigen status predict rotavirus vaccine take in infants

Abdul Momin Kazi, Margaret M. Cortese*, Ying Yu, Benjamin Lopman, Ardythe L. Morrow, Jessica A. Fleming, Monica M. McNeal, A. Duncan Steele, Umesh D. Parashar, Anita K.M. Zaidi, Asad Ali

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)

Abstract

Histo-blood group antigens (HBGAs) expressed on enterocytes are proposed receptors for rotaviruses and can be measured in saliva. Among 181 Pakistani infants in a G1P[8] rotavirus vaccine trial who were seronegative at baseline, anti-rotavirus immunoglobulin A seroconversion rates after 3 vaccine doses differed significantly by salivary HBGA phenotype, with the lowest rate (19%) among infants who were nonsecretors (ie, who did not express the carbohydrate synthesized by FUT2), an intermediate rate (30%) among secretors with non-blood group O, and the highest rate (51%) among secretors with O blood group. Differences in HBGA expression may be responsible for some of the discrepancy in the level of protection detected for the current rotavirus vaccines in low-income versus high-income settings.

Original languageEnglish
Pages (from-to)786-789
Number of pages4
JournalJournal of Infectious Diseases
Volume215
Issue number5
DOIs
Publication statusPublished - 1 Mar 2017
Externally publishedYes

Keywords

  • Blood group
  • FUT2
  • Infants
  • Lewis antigen
  • Rotavirus
  • Secretor
  • Vaccine

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