Soluble-fibre concentrate lowers plasminogen activator inhibitor-1 in baboons (Papio ursinus)

C. S. Venter; C. J. Nel; H. H. Vorster; J. C. Jerling; W. Oosthuizen; Frederick Johannes Veldman; J. A. Kellerman; C. M. Smuts; W. J.H. Vermaak; D. G. Van Der Nest; J. H. De Ridder

doi:10.1079/BJN19970179

Soluble-fibre concentrate lowers plasminogen activator inhibitor-1 in baboons (Papio ursinus)

C. S. Venter^*, C. J. Nel, H. H. Vorster, J. C. Jerling, W. Oosthuizen, Frederick Johannes Veldman, J. A. Kellerman, C. M. Smuts, W. J.H. Vermaak, D. G. Van Der Nest, J. H. De Ridder

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The effects of a soluble NSP (fibre) concentrate (SFC) on plasma fibrinogen and plasminogen activator inhibitor-1 (PAI-1), serum and liver lipids and lipoproteins and glucose tolerance were compared with those of bezafibrate (BF), a lipid-lowering drug, in obese baboons (Papio ursinus). The basal diet was a high-fat (37% of total energy), low-NSP (12.4 g/d) Westernized diet, supplemented for 8 weeks with either 20 SFCg/baboon per d or 6.7 mg BF/kg body weight per baboon per d, SFC supplementation significantly lowered PAI-1, total serum cholesterol, HDL-cholesterol and circulating free fatty acid levels. BF significantly lowered total serum cholesterol, but unexpectedly raised serum triacylglycerol levels. Although not statistically significant, the mean liver tricacylglycerol concentration of baboons fed on BF was lower than that of baboons fed on SFC supplements. These results suggest that: (1) the mechanism of action of the two cholesterol-lowering treatments differ, with BF having a liver triacylglycerol-lowering effect and (2) the SFC had additional beneficial effect on fibrinolysis by lowering PAI-1 levels.

Original language	English
Pages (from-to)	625-637
Number of pages	13
Journal	British Journal of Nutrition
Volume	78
Issue number	4
DOIs	https://doi.org/10.1079/BJN19970179 https://doi.org/10.1079/BJN19970179
Publication status	Published - Oct 1997
Externally published	Yes

Keywords

Baboons
Plasminogen activator inhibitor-1
Soluble-fibre concentrate

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Venter, C. S., Nel, C. J., Vorster, H. H., Jerling, J. C., Oosthuizen, W., Veldman, F. J., Kellerman, J. A., Smuts, C. M., Vermaak, W. J. H., Van Der Nest, D. G., & De Ridder, J. H. (1997). Soluble-fibre concentrate lowers plasminogen activator inhibitor-1 in baboons (Papio ursinus). British Journal of Nutrition, 78(4), 625-637. https://doi.org/10.1079/BJN19970179, https://doi.org/10.1079/BJN19970179

@article{764bfdc700f24c6b8234c241e2a3d3ea,

title = "Soluble-fibre concentrate lowers plasminogen activator inhibitor-1 in baboons (Papio ursinus)",

abstract = "The effects of a soluble NSP (fibre) concentrate (SFC) on plasma fibrinogen and plasminogen activator inhibitor-1 (PAI-1), serum and liver lipids and lipoproteins and glucose tolerance were compared with those of bezafibrate (BF), a lipid-lowering drug, in obese baboons (Papio ursinus). The basal diet was a high-fat (37% of total energy), low-NSP (12.4 g/d) Westernized diet, supplemented for 8 weeks with either 20 SFCg/baboon per d or 6.7 mg BF/kg body weight per baboon per d, SFC supplementation significantly lowered PAI-1, total serum cholesterol, HDL-cholesterol and circulating free fatty acid levels. BF significantly lowered total serum cholesterol, but unexpectedly raised serum triacylglycerol levels. Although not statistically significant, the mean liver tricacylglycerol concentration of baboons fed on BF was lower than that of baboons fed on SFC supplements. These results suggest that: (1) the mechanism of action of the two cholesterol-lowering treatments differ, with BF having a liver triacylglycerol-lowering effect and (2) the SFC had additional beneficial effect on fibrinolysis by lowering PAI-1 levels.",

keywords = "Baboons, Plasminogen activator inhibitor-1, Soluble-fibre concentrate",

author = "Venter, {C. S.} and Nel, {C. J.} and Vorster, {H. H.} and Jerling, {J. C.} and W. Oosthuizen and Veldman, {Frederick Johannes} and Kellerman, {J. A.} and Smuts, {C. M.} and Vermaak, {W. J.H.} and {Van Der Nest}, {D. G.} and {De Ridder}, {J. H.}",

note = "Funding Information: The authors are grateful to the South African Medical Research Council for their financial support, and to Boehringer Mannheim who kindly supplied the bezafibrate. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "1997",

month = oct,

doi = "10.1079/BJN19970179",

language = "English",

volume = "78",

pages = "625--637",

journal = "British Journal of Nutrition",

issn = "0007-1145",

publisher = "Cambridge University Press",

number = "4",

}

Venter, CS, Nel, CJ, Vorster, HH, Jerling, JC, Oosthuizen, W, Veldman, FJ, Kellerman, JA, Smuts, CM, Vermaak, WJH, Van Der Nest, DG & De Ridder, JH 1997, 'Soluble-fibre concentrate lowers plasminogen activator inhibitor-1 in baboons (Papio ursinus)', British Journal of Nutrition, vol. 78, no. 4, pp. 625-637. https://doi.org/10.1079/BJN19970179, https://doi.org/10.1079/BJN19970179

TY - JOUR

T1 - Soluble-fibre concentrate lowers plasminogen activator inhibitor-1 in baboons (Papio ursinus)

AU - Venter, C. S.

AU - Nel, C. J.

AU - Vorster, H. H.

AU - Jerling, J. C.

AU - Oosthuizen, W.

AU - Veldman, Frederick Johannes

AU - Kellerman, J. A.

AU - Smuts, C. M.

AU - Vermaak, W. J.H.

AU - Van Der Nest, D. G.

AU - De Ridder, J. H.

N1 - Funding Information: The authors are grateful to the South African Medical Research Council for their financial support, and to Boehringer Mannheim who kindly supplied the bezafibrate. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 1997/10

Y1 - 1997/10

N2 - The effects of a soluble NSP (fibre) concentrate (SFC) on plasma fibrinogen and plasminogen activator inhibitor-1 (PAI-1), serum and liver lipids and lipoproteins and glucose tolerance were compared with those of bezafibrate (BF), a lipid-lowering drug, in obese baboons (Papio ursinus). The basal diet was a high-fat (37% of total energy), low-NSP (12.4 g/d) Westernized diet, supplemented for 8 weeks with either 20 SFCg/baboon per d or 6.7 mg BF/kg body weight per baboon per d, SFC supplementation significantly lowered PAI-1, total serum cholesterol, HDL-cholesterol and circulating free fatty acid levels. BF significantly lowered total serum cholesterol, but unexpectedly raised serum triacylglycerol levels. Although not statistically significant, the mean liver tricacylglycerol concentration of baboons fed on BF was lower than that of baboons fed on SFC supplements. These results suggest that: (1) the mechanism of action of the two cholesterol-lowering treatments differ, with BF having a liver triacylglycerol-lowering effect and (2) the SFC had additional beneficial effect on fibrinolysis by lowering PAI-1 levels.

AB - The effects of a soluble NSP (fibre) concentrate (SFC) on plasma fibrinogen and plasminogen activator inhibitor-1 (PAI-1), serum and liver lipids and lipoproteins and glucose tolerance were compared with those of bezafibrate (BF), a lipid-lowering drug, in obese baboons (Papio ursinus). The basal diet was a high-fat (37% of total energy), low-NSP (12.4 g/d) Westernized diet, supplemented for 8 weeks with either 20 SFCg/baboon per d or 6.7 mg BF/kg body weight per baboon per d, SFC supplementation significantly lowered PAI-1, total serum cholesterol, HDL-cholesterol and circulating free fatty acid levels. BF significantly lowered total serum cholesterol, but unexpectedly raised serum triacylglycerol levels. Although not statistically significant, the mean liver tricacylglycerol concentration of baboons fed on BF was lower than that of baboons fed on SFC supplements. These results suggest that: (1) the mechanism of action of the two cholesterol-lowering treatments differ, with BF having a liver triacylglycerol-lowering effect and (2) the SFC had additional beneficial effect on fibrinolysis by lowering PAI-1 levels.

KW - Baboons

KW - Plasminogen activator inhibitor-1

KW - Soluble-fibre concentrate

UR - http://www.scopus.com/inward/record.url?scp=17444454589&partnerID=8YFLogxK

U2 - 10.1079/BJN19970179

DO - 10.1079/BJN19970179

M3 - Article

C2 - 9389888

SN - 0007-1145

VL - 78

SP - 625

EP - 637

JO - British Journal of Nutrition

JF - British Journal of Nutrition

IS - 4

ER -

Soluble-fibre concentrate lowers plasminogen activator inhibitor-1 in baboons (Papio ursinus)

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