Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN): An update

O. Mogole, Natalie Schellack*, Mojakgomo Hendrick Motswaledi

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review


© 2016 The Author(s). Stevens-Johnson syndrome (SJS) is a form of toxic epidermal necrolysis (TEN) a rare but life-threatening hypersensitivity reactions that affect the skin and mucous membranes. The most common triggers are drugs, but they can also be triggered by infections. Granulysin has been recently identified as the major molecule responsible for the widespread keratinocyte necrosis. Early identification and removal of causative agent is crucial in preventing progression of condition and reducing patient mortality. Supportive care is often recommended over immunomodulating treatments as it helps improve patient outcome.
Original languageEnglish
Pages (from-to)57-59
Number of pages3
JournalSouth African Family Practice
Issue number5
Publication statusPublished - 1 Sept 2016


  • Granulysin
  • Hypersensitivity
  • Immunomodulating
  • Steven-Johnsons syndrome (SJS)
  • Supportive care
  • Toxic epidermal necrolysis (TEN)


Dive into the research topics of 'Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN): An update'. Together they form a unique fingerprint.

Cite this