TY - JOUR
T1 - Synthesis, antibacterial activity and docking studies of benzyl alcohol derivatives
AU - Sulaiman, Mamman
AU - Hassan, Yusuf
AU - Taskin-Tok, Tugba
AU - Noundou, Xavier Siwe
N1 - Publisher Copyright:
© 2020, Turkish Chemical Society. All rights reserved.
PY - 2020
Y1 - 2020
N2 - Benzyl alcohol derivatives were synthesized, and characterized using NMR and FTIR spectroscopic techniques. For the first time, the antibacterial activities of the synthesized compounds were examined using disc diffusion method by measuring the diameter of the zones of inhibition against Staphylococcus aureus and Pseudomonas aeruginosa. The results demonstrated that the activity was concentration dependant, and that the compounds were generally potent against P. aeruginosa. Only two of the compounds were active against S. aureus. In terms of broad spectrum activity, compound 2d (35 mm) was found to exhibit a promising efficacy which surpassed that of the standard drug (amoxicillin).The binding of compounds 2a-e to the glucosamine-6-phosphate synthase (GlcN-6-P) active-site revealed that all the synthesized compounds fitted into the GlcN-6-P active-site receptor cavity, exhibited potential hydrogen-bonding interactions with the proximal amino acid residues and aligned similar to amoxicillin. Interestingly, it has been found that the most active compound, 2d also appeared to have a relatively low binding energy (-52.8901 kcal/mol).
AB - Benzyl alcohol derivatives were synthesized, and characterized using NMR and FTIR spectroscopic techniques. For the first time, the antibacterial activities of the synthesized compounds were examined using disc diffusion method by measuring the diameter of the zones of inhibition against Staphylococcus aureus and Pseudomonas aeruginosa. The results demonstrated that the activity was concentration dependant, and that the compounds were generally potent against P. aeruginosa. Only two of the compounds were active against S. aureus. In terms of broad spectrum activity, compound 2d (35 mm) was found to exhibit a promising efficacy which surpassed that of the standard drug (amoxicillin).The binding of compounds 2a-e to the glucosamine-6-phosphate synthase (GlcN-6-P) active-site revealed that all the synthesized compounds fitted into the GlcN-6-P active-site receptor cavity, exhibited potential hydrogen-bonding interactions with the proximal amino acid residues and aligned similar to amoxicillin. Interestingly, it has been found that the most active compound, 2d also appeared to have a relatively low binding energy (-52.8901 kcal/mol).
KW - Antibacterial activity
KW - Benzyl alcohol derivatives
KW - Docking studies
KW - Glucosamine-6-phosphate synthase
UR - http://www.scopus.com/inward/record.url?scp=85090705595&partnerID=8YFLogxK
U2 - 10.18596/jotcsa.692113.
DO - 10.18596/jotcsa.692113.
M3 - Article
AN - SCOPUS:85090705595
SN - 2149-0120
VL - 7
SP - 481
EP - 488
JO - Journal of the Turkish Chemical Society, Section A: Chemistry
JF - Journal of the Turkish Chemical Society, Section A: Chemistry
IS - 2
ER -