Synthesis, antibacterial activity and docking studies of benzyl alcohol derivatives

Mamman Sulaiman, Yusuf Hassan*, Tugba Taskin-Tok, Xavier Siwe Noundou

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Benzyl alcohol derivatives were synthesized, and characterized using NMR and FTIR spectroscopic techniques. For the first time, the antibacterial activities of the synthesized compounds were examined using disc diffusion method by measuring the diameter of the zones of inhibition against Staphylococcus aureus and Pseudomonas aeruginosa. The results demonstrated that the activity was concentration dependant, and that the compounds were generally potent against P. aeruginosa. Only two of the compounds were active against S. aureus. In terms of broad spectrum activity, compound 2d (35 mm) was found to exhibit a promising efficacy which surpassed that of the standard drug (amoxicillin).The binding of compounds 2a-e to the glucosamine-6-phosphate synthase (GlcN-6-P) active-site revealed that all the synthesized compounds fitted into the GlcN-6-P active-site receptor cavity, exhibited potential hydrogen-bonding interactions with the proximal amino acid residues and aligned similar to amoxicillin. Interestingly, it has been found that the most active compound, 2d also appeared to have a relatively low binding energy (-52.8901 kcal/mol).

Original languageEnglish
Pages (from-to)481-488
Number of pages8
JournalJournal of the Turkish Chemical Society, Section A: Chemistry
Issue number2
Publication statusPublished - 2020
Externally publishedYes


  • Antibacterial activity
  • Benzyl alcohol derivatives
  • Docking studies
  • Glucosamine-6-phosphate synthase


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