@article{0b6de10d7804420e872b8b1d0138dda8,
title = "Synthesis of cyclic dimeric methyl morpholinoside - A common synthetic precursor to cyclic dinucleotide analogs",
abstract = "An eight-step synthesis of cyclic dimeric methyl morpholinoside (c-di-MM), a common synthetic precursor to a number of cyclic dinucleotide analogs is reported. The synthesis of c-di-MM proceeds through a morpholine monomer prepared from readily available inexpensive starting materials and culminates with a key macrolactamization reaction to provide the macrocycle in 15% overall yield.",
keywords = "Morpholine, Second messenger molecule, Signaling nucleotide, c-di-AMP, c-di-GMP",
author = "Kinzie, {Charles R.} and Steele, {Andrew D.} and Pasciolla, {Stacy M.} and Wuest, {William M.}",
note = "Funding Information: The authors would like to thank Dr. Charles Debrosse and Ms. Madison Fletcher for spectroscopic assistance and Professor Herman Sintim (University of Maryland) for helpful discussions. Financial support was provided by the Charles E. Kaufman Fund of The Pittsburgh Foundation ( UN2013-66931 ), the Pennsylvania Department of Health ( PADOH 4100057683 ), and Temple University in the form of research support (W.M.W.) and an URP fellowship (S.M.P.). Publisher Copyright: {\textcopyright} 2014 Elsevier Ltd. All rights reserved.",
year = "2014",
doi = "10.1016/j.tetlet.2014.07.038",
language = "English",
volume = "55",
pages = "4966--4968",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Ltd.",
number = "35",
}