TY - JOUR
T1 - Ten-year kidney transplant survival of cyclosporine- or tacrolimus-treated patients in Brazil
AU - Gomes, Rosângela Maria
AU - Guerra Júnior, Augusto Afonso
AU - de Lemos, Lívia Lovato Pires
AU - Costa, Juliana de Oliveira
AU - Almeida, Alessandra Maciel
AU - Alvares, Juliana
AU - Filho, Charles Simão
AU - Cherchiglia, Mariângela Leal
AU - Andrade, Eli Iola Gurgel
AU - Godman, Brian
AU - Acurcio, Francisco Assis
N1 - Publisher Copyright:
© 2016 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2016/7/2
Y1 - 2016/7/2
N2 - Background: Cyclosporine and tacrolimus are well established immunosuppressants; however little is known about long term survival rates. The project aim was to compare 10-year graft survival and associated factors among kidney transplant patients within the Brazilian Public Health System (SUS) prescribed either immunosuppressant. Methods: Analyze a national cohort of kidney transplant recipients within SUS. Graft loss defined by death or dialysis for more than three months. Kaplan-Meier method used to estimate cumulative probabilities of survival. Cox proportional hazards model used to evaluate factors associated with progression to graft loss. Results: 13,811 patients were included, 5,887 used cyclosporine and 7,924 tacrolimus. A higher risk of graft loss was associated with tacrolimus, a deceased donor, additional years of age, median period of dialysis greater than 47 months, diagnosis of diabetes as the primary cause of chronic kidney disease and transplantation between 2005 and 2009. Conclusions: Among other factors, tacrolimus-based regimens were associated with worse graft survival.
AB - Background: Cyclosporine and tacrolimus are well established immunosuppressants; however little is known about long term survival rates. The project aim was to compare 10-year graft survival and associated factors among kidney transplant patients within the Brazilian Public Health System (SUS) prescribed either immunosuppressant. Methods: Analyze a national cohort of kidney transplant recipients within SUS. Graft loss defined by death or dialysis for more than three months. Kaplan-Meier method used to estimate cumulative probabilities of survival. Cox proportional hazards model used to evaluate factors associated with progression to graft loss. Results: 13,811 patients were included, 5,887 used cyclosporine and 7,924 tacrolimus. A higher risk of graft loss was associated with tacrolimus, a deceased donor, additional years of age, median period of dialysis greater than 47 months, diagnosis of diabetes as the primary cause of chronic kidney disease and transplantation between 2005 and 2009. Conclusions: Among other factors, tacrolimus-based regimens were associated with worse graft survival.
KW - Brazil
KW - Cyclosporine
KW - Graft survival
KW - Immunosuppressants
KW - Kidney transplantation
KW - Survival rates
KW - Tacrolimus
UR - http://www.scopus.com/inward/record.url?scp=84976586785&partnerID=8YFLogxK
U2 - 10.1080/17512433.2016.1190270
DO - 10.1080/17512433.2016.1190270
M3 - Article
C2 - 27181131
AN - SCOPUS:84976586785
SN - 1751-2433
VL - 9
SP - 991
EP - 999
JO - Expert Review of Clinical Pharmacology
JF - Expert Review of Clinical Pharmacology
IS - 7
ER -
