The clinical effectiveness of insulin glargine in patients with type I diabetes in Brazil: Findings and implications

Lays P. Marra, Vania E. Araujo, Gerusa C.C. Oliveira, Leonardo M. Diniz, Augusto A.Guerra Junior, Francisco De Assis Acurcio, Brian Godman*, Juliana Alvares

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Aim: Published studies have challenged the cost-effectiveness of insulin glargine versus neutral protamine hagedorn (NPH) insulins in Brazil with limited evidence of increased effectiveness despite considerably higher acquisition costs. However, still a controversy. Consequently, there is a need to address this. Materials & methods: Retrospective cohort study of Type I diabetes patients receiving insulin glargine in Brazil following NPH insulin who met the criteria. Results: 580 patients were enrolled. HbA1c varied from 8.80 ± 1.98% in NPH insulin users to 8.54 ± 1.88% after insulin glargine for 6 months, which is not clinically significant. Frequency of glycemic control varied from 22.6% with NPH insulin to 26.2% with insulin glargine. No statistically significant difference was observed between controlled and still uncontrolled groups for all analyzed factors including type and frequency of insulin use and carbohydrate counting. Conclusion: Limited differences between NPH insulins and insulin analogs in routine clinical care do not justify an appreciable cost difference.

Original languageEnglish
Pages (from-to)519-527
Number of pages9
JournalJournal of Comparative Effectiveness Research
Volume6
Issue number6
DOIs
Publication statusPublished - 2017
Externally publishedYes

Keywords

  • Brazil
  • Comparative effectiveness research
  • Insulin glargine
  • Longitudinal studies
  • NPH insulin
  • Type I diabetes

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