The pathobiology and mechanisms of infection of HPV.

N. H. Wood*, R. A. Khammissa, U. M. Chikte, R. Meyerov, J. Lemmer, L. Feller

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


There are more than 120 types of low-risk and high-risk human papillomaviruses, all of which are epitheliotropic. HPV infection may be latent, or active in a subclinical form or a symptomatic form, the latter manifesting as benign or malignant neoplasms. In basal cells with non-productive HPV infection some early HPV proteins are expressed independently of cell maturation: the productive cycle of HPV replication depends upon specific cellular factors of the maturation of the infected keratinocytes. In HPV-mediated oncogenesis, the combined pathobiological effects of E6 and E7 oncoproteins of high-risk HPV culminate in cellular genomic instability and transformation of persistently infected cells, that progress to the development of a malignant phenotype. In this article we provide insights into the stages of HPV infection, and into the viral genomic organization and replicative cycle.

Original languageEnglish
Pages (from-to)124-126
Number of pages3
JournalSADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging
Issue number3
Publication statusPublished - Apr 2010
Externally publishedYes


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