The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma

L. Feller; J. N. Masipa; N. H. Wood; E. J. Raubenheimer; J. Lemmer

doi:10.1186/1742-6405-5-2

The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma

L. Feller^*, J. N. Masipa, N. H. Wood, E. J. Raubenheimer, J. Lemmer

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Background: Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to cause HIV-KS, the development of which is influenced by HIV, by increased production of cytokines and by growth factors. Whether HIV-KS is a true malignancy or a reactive hyperplastic inflammatory condition is debatable. Results and Conclusion: Oedema of the face, legs and hands is a prominent feature of HIV-KS and is probably caused by lymphoedema related to the HIV-KS lesions. The cases of two HIV-seropositive subjects with KS-associated facial lymphoedema are reported. Extensive oral HIV-KS in association with facial oedema in the absence of anti-retroviral treatment appears to be an indication of a poor prognosis.

Original language	English
Article number	2
Journal	AIDS Research and Therapy
Volume	5
DOIs	https://doi.org/10.1186/1742-6405-5-2
Publication status	Published - 29 Jan 2008
Externally published	Yes

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title = "The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma",

abstract = "Background: Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to cause HIV-KS, the development of which is influenced by HIV, by increased production of cytokines and by growth factors. Whether HIV-KS is a true malignancy or a reactive hyperplastic inflammatory condition is debatable. Results and Conclusion: Oedema of the face, legs and hands is a prominent feature of HIV-KS and is probably caused by lymphoedema related to the HIV-KS lesions. The cases of two HIV-seropositive subjects with KS-associated facial lymphoedema are reported. Extensive oral HIV-KS in association with facial oedema in the absence of anti-retroviral treatment appears to be an indication of a poor prognosis.",

author = "L. Feller and Masipa, {J. N.} and Wood, {N. H.} and Raubenheimer, {E. J.} and J. Lemmer",

year = "2008",

month = jan,

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doi = "10.1186/1742-6405-5-2",

language = "English",

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journal = "AIDS Research and Therapy",

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TY - JOUR

T1 - The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma

AU - Feller, L.

AU - Masipa, J. N.

AU - Wood, N. H.

AU - Raubenheimer, E. J.

AU - Lemmer, J.

PY - 2008/1/29

Y1 - 2008/1/29

N2 - Background: Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to cause HIV-KS, the development of which is influenced by HIV, by increased production of cytokines and by growth factors. Whether HIV-KS is a true malignancy or a reactive hyperplastic inflammatory condition is debatable. Results and Conclusion: Oedema of the face, legs and hands is a prominent feature of HIV-KS and is probably caused by lymphoedema related to the HIV-KS lesions. The cases of two HIV-seropositive subjects with KS-associated facial lymphoedema are reported. Extensive oral HIV-KS in association with facial oedema in the absence of anti-retroviral treatment appears to be an indication of a poor prognosis.

AB - Background: Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to cause HIV-KS, the development of which is influenced by HIV, by increased production of cytokines and by growth factors. Whether HIV-KS is a true malignancy or a reactive hyperplastic inflammatory condition is debatable. Results and Conclusion: Oedema of the face, legs and hands is a prominent feature of HIV-KS and is probably caused by lymphoedema related to the HIV-KS lesions. The cases of two HIV-seropositive subjects with KS-associated facial lymphoedema are reported. Extensive oral HIV-KS in association with facial oedema in the absence of anti-retroviral treatment appears to be an indication of a poor prognosis.

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DO - 10.1186/1742-6405-5-2

M3 - Article

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SN - 1742-6405

VL - 5

JO - AIDS Research and Therapy

JF - AIDS Research and Therapy

M1 - 2

ER -

The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma

Abstract

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