The Role of Bone Remodelling in Maintaining and Restoring Bone Health: an Overview

E. Raubenheimer*, H. Miniggio, L. Lemmer, W. van Heerden

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Autocrine, paracrine and endocrine signals regulate the activities of cells involved in skeletal remodelling. Mapping of the metabolic pathways of bone cells and characterization of their chemical mediators have prompted the pharmaceutical industry to develop patented drugs and auto-antibodies which modulate the anabolic and catabolic activities in bone. This overview provides insight into the metabolic pathways which govern bone cells involved in bone metabolism as a framework for understanding the progress made in the pharmaceutical manipulation of skeletal health.

Original languageEnglish
Pages (from-to)90-97
Number of pages8
JournalClinical Reviews in Bone and Mineral Metabolism
Volume15
Issue number2
DOIs
Publication statusPublished - 1 Jun 2017

Keywords

  • Bone remodelling
  • Osteoblast
  • Osteoclast
  • Osteocyte
  • Skeletal health

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