The Role of Bone Remodelling in Maintaining and Restoring Bone Health: an Overview

E. Raubenheimer; H. Miniggio; L. Lemmer; W. van Heerden

doi:10.1007/s12018-017-9230-z

The Role of Bone Remodelling in Maintaining and Restoring Bone Health: an Overview

E. Raubenheimer^*, H. Miniggio, L. Lemmer, W. van Heerden

^*Corresponding author for this work

Oral Biology

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Autocrine, paracrine and endocrine signals regulate the activities of cells involved in skeletal remodelling. Mapping of the metabolic pathways of bone cells and characterization of their chemical mediators have prompted the pharmaceutical industry to develop patented drugs and auto-antibodies which modulate the anabolic and catabolic activities in bone. This overview provides insight into the metabolic pathways which govern bone cells involved in bone metabolism as a framework for understanding the progress made in the pharmaceutical manipulation of skeletal health.

Original language	English
Pages (from-to)	90-97
Number of pages	8
Journal	Clinical Reviews in Bone and Mineral Metabolism
Volume	15
Issue number	2
DOIs	https://doi.org/10.1007/s12018-017-9230-z
Publication status	Published - 1 Jun 2017

Keywords

Bone remodelling
Osteoblast
Osteoclast
Osteocyte
Skeletal health

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abstract = "Autocrine, paracrine and endocrine signals regulate the activities of cells involved in skeletal remodelling. Mapping of the metabolic pathways of bone cells and characterization of their chemical mediators have prompted the pharmaceutical industry to develop patented drugs and auto-antibodies which modulate the anabolic and catabolic activities in bone. This overview provides insight into the metabolic pathways which govern bone cells involved in bone metabolism as a framework for understanding the progress made in the pharmaceutical manipulation of skeletal health.",

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AU - van Heerden, W.

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KW - Osteoblast

KW - Osteoclast

KW - Osteocyte

KW - Skeletal health

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The Role of Bone Remodelling in Maintaining and Restoring Bone Health: an Overview

Abstract

Keywords

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