Three new pentacyclic triterpenoids from twigs of Manniophyton fulvum (Euphorbiaceae)

Ahri Bernie Djamen Mbeunkeu, Anatole Guy Blaise Azebaze*, Michel Feussi Tala, Jean Emmanuel Mbosso Teinkela, Xavier Siwe Noundou, Rui Werner Maçedo Krause, Juliette Catherine Vardamides, Hartmut Laatsch

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Phytochemical investigation of the methanol extracts of the twigs of Manniophyton fulvum has led to the isolation and characterization of three new pentacyclic triterpenoids, designated as 3α,28-dihydroxyfriedelan-1-one (1), manniotaraxerol A (3) and manniotaraxerol B (4), along with fourteen known compounds, 3α-hydroxy-1-oxofriedelane (2), betulinic acid (5), friedelin (S1), taraxerol (S2), a mixture of stigmasterol (S3) and β-sitosterol (S4), herranone (S5), docosanoic acid (S6), ursolic acid (S7), nasutin B (S8), bergenin (S9), stigmasterol-3-O-β-D-glucopyranoside (S10), 1,2-di-O-palmitoyl-3-O-(6-sulfo-α-D-quinovopyranosyl)glycerol (S11), and aridanin (S12). The structures of all compounds were determined by comprehensive spectroscopic analyses (1D and 2D NMR, EI and ESI-MS). 3α,28-Dihydroxyfriedelan-1-one (1), 3α-hydroxy-1-oxofriedelane (2), manniotaraxerol A (3), manniotaraxerol B (4), and betulinic acid (5) were evaluated against HeLa (human cervix adenocarcinoma) cancer cells. Manniotaraxerol A (3) showed weak in vitro cytotoxicity with a cell viability value of 49.3%. Betulinic acid (5) also showed significant cytotoxicity against HeLa cell with a cell viability value of 4.0%; the other compounds were inactive in this test.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalPhytochemistry Letters
Publication statusPublished - Oct 2018
Externally publishedYes


  • Cytotoxic activity
  • Euphorbiaceae
  • Manniophyton fulvum
  • Pentacyclic triterpenoids


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