Tools for genotyping human immunodeficiency virus, and implications of genetic diversity on diagnostics, treatment and prevention

Pascal Obong Bessong, Benson Chuks Iweriebor, Lufuno Grace Mavhandu, Tracy Masebe, Julius Nwobegahay

Research output: Contribution to journalReview articlepeer-review

Abstract

Human immunodeficiency virus (HIV) presents an unprecedented genetic variability within infected individuals and across geographical locales. Sub-Saharan Africa accounts for almost 70% of all HIV infections worldwide and represents the region with the highest diversity of genetic variants of the virus. This review looks at the current approaches and techniques for the determination of HIV genetic diversity. In addition, the rationale for a continuous periodic monitoring6 of the genetic landscape due to the implications of shifting genetics on the efficacy of diagnostics, treatment and prevention strategies is highlighted. copy; 2008 Academic Journals.

Original languageEnglish
Pages (from-to)4774-4783
Number of pages10
JournalAfrican Journal of Biotechnology
Volume7
Issue number25
Publication statusPublished - 29 Dec 2008
Externally publishedYes

Keywords

  • Diagnostics
  • Genetic diversity
  • Genotyping
  • HIV
  • Prevention
  • Treatment

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