Transmission of a homogeneous hepatitis B virus population of A1896- containing strains leading to mild resolving acute hepatitis and seroconversion to hepatitis B e antigen antibodies in an adult

M. Jeffrey Mphahlele, Alan G. Shattock, Winifred Boner, Jacqueline Quinn, P. Aiden McCormick, William F. Carman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The pre-core variant, A1896, which switches off hepatitis B e antigen (HBeAg) production, is common in hepatitis B e antigen antibody (anti-HBe)-positive chronic hepatitis patients. It has been observed in occasional case reports of acute hepatitis. However, transmission in the absence of HBeAgproducing strains, leading to acute nonfulminant hepatitis and clearance in adults, has not been reported. Here, we show that this event can occur, further confirming that A1896 strains are 'wild-type' and can lead to all the same outcomes as G1896 strains. This is in keeping with phylogenetic evidence that A1896 is transmitted independently on a large scale in the population and explains anti-HBe- positive persons who have not had an HBeAg-positive phase documented.

Original languageEnglish
Pages (from-to)743-746
Number of pages4
JournalHepatology
Volume26
Issue number3
DOIs
Publication statusPublished - Sep 1997
Externally publishedYes

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