Transmission of a homogeneous hepatitis B virus population of A1896- containing strains leading to mild resolving acute hepatitis and seroconversion to hepatitis B e antigen antibodies in an adult

M. Jeffrey Mphahlele; Alan G. Shattock; Winifred Boner; Jacqueline Quinn; P. Aiden McCormick; William F. Carman

doi:10.1002/hep.510260329

Transmission of a homogeneous hepatitis B virus population of A₁₈₉₆- containing strains leading to mild resolving acute hepatitis and seroconversion to hepatitis B e antigen antibodies in an adult

M. Jeffrey Mphahlele, Alan G. Shattock, Winifred Boner, Jacqueline Quinn, P. Aiden McCormick, William F. Carman^*

^*Corresponding author for this work

Virological Pathology

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22 Citations (Scopus)

Abstract

The pre-core variant, A₁₈₉₆, which switches off hepatitis B e antigen (HBeAg) production, is common in hepatitis B e antigen antibody (anti-HBe)-positive chronic hepatitis patients. It has been observed in occasional case reports of acute hepatitis. However, transmission in the absence of HBeAgproducing strains, leading to acute nonfulminant hepatitis and clearance in adults, has not been reported. Here, we show that this event can occur, further confirming that A₁₈₉₆ strains are 'wild-type' and can lead to all the same outcomes as G₁₈₉₆ strains. This is in keeping with phylogenetic evidence that A₁₈₉₆ is transmitted independently on a large scale in the population and explains anti-HBe- positive persons who have not had an HBeAg-positive phase documented.

Original language	English
Pages (from-to)	743-746
Number of pages	4
Journal	Hepatology
Volume	26
Issue number	3
DOIs	https://doi.org/10.1002/hep.510260329
Publication status	Published - Sept 1997

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10.1002/hep.510260329

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@article{a95734ca2b994d128cb5150161983441,

title = "Transmission of a homogeneous hepatitis B virus population of A1896- containing strains leading to mild resolving acute hepatitis and seroconversion to hepatitis B e antigen antibodies in an adult",

abstract = "The pre-core variant, A1896, which switches off hepatitis B e antigen (HBeAg) production, is common in hepatitis B e antigen antibody (anti-HBe)-positive chronic hepatitis patients. It has been observed in occasional case reports of acute hepatitis. However, transmission in the absence of HBeAgproducing strains, leading to acute nonfulminant hepatitis and clearance in adults, has not been reported. Here, we show that this event can occur, further confirming that A1896 strains are 'wild-type' and can lead to all the same outcomes as G1896 strains. This is in keeping with phylogenetic evidence that A1896 is transmitted independently on a large scale in the population and explains anti-HBe- positive persons who have not had an HBeAg-positive phase documented.",

author = "Mphahlele, {M. Jeffrey} and Shattock, {Alan G.} and Winifred Boner and Jacqueline Quinn and McCormick, {P. Aiden} and Carman, {William F.}",

year = "1997",

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doi = "10.1002/hep.510260329",

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Transmission of a homogeneous hepatitis B virus population of A₁₈₉₆- containing strains leading to mild resolving acute hepatitis and seroconversion to hepatitis B e antigen antibodies in an adult. / Mphahlele, M. Jeffrey; Shattock, Alan G.; Boner, Winifred et al.
In: Hepatology, Vol. 26, No. 3, 09.1997, p. 743-746.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Transmission of a homogeneous hepatitis B virus population of A1896- containing strains leading to mild resolving acute hepatitis and seroconversion to hepatitis B e antigen antibodies in an adult

AU - Mphahlele, M. Jeffrey

AU - Shattock, Alan G.

AU - Boner, Winifred

AU - Quinn, Jacqueline

AU - McCormick, P. Aiden

AU - Carman, William F.

PY - 1997/9

Y1 - 1997/9

N2 - The pre-core variant, A1896, which switches off hepatitis B e antigen (HBeAg) production, is common in hepatitis B e antigen antibody (anti-HBe)-positive chronic hepatitis patients. It has been observed in occasional case reports of acute hepatitis. However, transmission in the absence of HBeAgproducing strains, leading to acute nonfulminant hepatitis and clearance in adults, has not been reported. Here, we show that this event can occur, further confirming that A1896 strains are 'wild-type' and can lead to all the same outcomes as G1896 strains. This is in keeping with phylogenetic evidence that A1896 is transmitted independently on a large scale in the population and explains anti-HBe- positive persons who have not had an HBeAg-positive phase documented.

AB - The pre-core variant, A1896, which switches off hepatitis B e antigen (HBeAg) production, is common in hepatitis B e antigen antibody (anti-HBe)-positive chronic hepatitis patients. It has been observed in occasional case reports of acute hepatitis. However, transmission in the absence of HBeAgproducing strains, leading to acute nonfulminant hepatitis and clearance in adults, has not been reported. Here, we show that this event can occur, further confirming that A1896 strains are 'wild-type' and can lead to all the same outcomes as G1896 strains. This is in keeping with phylogenetic evidence that A1896 is transmitted independently on a large scale in the population and explains anti-HBe- positive persons who have not had an HBeAg-positive phase documented.

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U2 - 10.1002/hep.510260329

DO - 10.1002/hep.510260329

M3 - Article

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AN - SCOPUS:0030612251

SN - 0270-9139

VL - 26

SP - 743

EP - 746

JO - Hepatology

JF - Hepatology

IS - 3

ER -

Transmission of a homogeneous hepatitis B virus population of A₁₈₉₆- containing strains leading to mild resolving acute hepatitis and seroconversion to hepatitis B e antigen antibodies in an adult

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